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Aetiology of acute diarrhoea in children in Shanghai, 2015–2018
Diarrhoea remains a major cause of childhood morbidity and mortality worldwide. This study aimed to monitor the aetiology of acute diarrhoea in children in Shanghai. Paediatric outpatients with acute diarrhoea were enrolled in the study from Jan 2015 to Dec 2018. Faecal samples were collected for te...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031434/ https://www.ncbi.nlm.nih.gov/pubmed/33831124 http://dx.doi.org/10.1371/journal.pone.0249888 |
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author | Chang, Hailing Guo, Jiayin Wei, Zhongqiu Huang, Zheng Wang, Chuning Qiu, Yue Xu, Xuebin Zeng, Mei |
author_facet | Chang, Hailing Guo, Jiayin Wei, Zhongqiu Huang, Zheng Wang, Chuning Qiu, Yue Xu, Xuebin Zeng, Mei |
author_sort | Chang, Hailing |
collection | PubMed |
description | Diarrhoea remains a major cause of childhood morbidity and mortality worldwide. This study aimed to monitor the aetiology of acute diarrhoea in children in Shanghai. Paediatric outpatients with acute diarrhoea were enrolled in the study from Jan 2015 to Dec 2018. Faecal samples were collected for testing. Enteric bacteria were identified and typed by culture and serotyping, respectively. Enteric viruses were identified by real-time PCR. Enteric pathogens were identified in 1572 (58.4%) of the 2692 enrolled children with acute diarrhoea. Viruses were detected more frequently than bacteria (41.3% versus 25.0%). Nontyphoidal Salmonella spp. (NTS) was the most common (10.3%) bacteria isolated, followed by enteropathogenic Escherichia coli (EPEC) (6.5%), enteroaggregative Escherichia coli (EAEC) (6.2%), Campylobacter spp. (3.6%), enterotoxigenic Escherichia coli (ETEC) (1.1%), Shigella spp. (0.2%), and enterohemorrhagic Escherichia coli (EHEC) (0.1%). Rotavirus was the most common (16.0%) virus detected, followed by norovirus (15.5%), adenovirus (7.2%), sapovirus (3.0%) and astrovirus (2.7%). Rotavirus, norovirus and NTS were the major pathogens responsible for diarrhoea in Shanghainese children. Improving uptake of the rotavirus vaccine and strengthening foodborne-pathogen prevention will aid in reducing the burden of diarrhoeal disease in children in Shanghai. |
format | Online Article Text |
id | pubmed-8031434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80314342021-04-14 Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 Chang, Hailing Guo, Jiayin Wei, Zhongqiu Huang, Zheng Wang, Chuning Qiu, Yue Xu, Xuebin Zeng, Mei PLoS One Research Article Diarrhoea remains a major cause of childhood morbidity and mortality worldwide. This study aimed to monitor the aetiology of acute diarrhoea in children in Shanghai. Paediatric outpatients with acute diarrhoea were enrolled in the study from Jan 2015 to Dec 2018. Faecal samples were collected for testing. Enteric bacteria were identified and typed by culture and serotyping, respectively. Enteric viruses were identified by real-time PCR. Enteric pathogens were identified in 1572 (58.4%) of the 2692 enrolled children with acute diarrhoea. Viruses were detected more frequently than bacteria (41.3% versus 25.0%). Nontyphoidal Salmonella spp. (NTS) was the most common (10.3%) bacteria isolated, followed by enteropathogenic Escherichia coli (EPEC) (6.5%), enteroaggregative Escherichia coli (EAEC) (6.2%), Campylobacter spp. (3.6%), enterotoxigenic Escherichia coli (ETEC) (1.1%), Shigella spp. (0.2%), and enterohemorrhagic Escherichia coli (EHEC) (0.1%). Rotavirus was the most common (16.0%) virus detected, followed by norovirus (15.5%), adenovirus (7.2%), sapovirus (3.0%) and astrovirus (2.7%). Rotavirus, norovirus and NTS were the major pathogens responsible for diarrhoea in Shanghainese children. Improving uptake of the rotavirus vaccine and strengthening foodborne-pathogen prevention will aid in reducing the burden of diarrhoeal disease in children in Shanghai. Public Library of Science 2021-04-08 /pmc/articles/PMC8031434/ /pubmed/33831124 http://dx.doi.org/10.1371/journal.pone.0249888 Text en © 2021 Chang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Chang, Hailing Guo, Jiayin Wei, Zhongqiu Huang, Zheng Wang, Chuning Qiu, Yue Xu, Xuebin Zeng, Mei Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 |
title | Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 |
title_full | Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 |
title_fullStr | Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 |
title_full_unstemmed | Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 |
title_short | Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 |
title_sort | aetiology of acute diarrhoea in children in shanghai, 2015–2018 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031434/ https://www.ncbi.nlm.nih.gov/pubmed/33831124 http://dx.doi.org/10.1371/journal.pone.0249888 |
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