Cargando…

Aetiology of acute diarrhoea in children in Shanghai, 2015–2018

Diarrhoea remains a major cause of childhood morbidity and mortality worldwide. This study aimed to monitor the aetiology of acute diarrhoea in children in Shanghai. Paediatric outpatients with acute diarrhoea were enrolled in the study from Jan 2015 to Dec 2018. Faecal samples were collected for te...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Hailing, Guo, Jiayin, Wei, Zhongqiu, Huang, Zheng, Wang, Chuning, Qiu, Yue, Xu, Xuebin, Zeng, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031434/
https://www.ncbi.nlm.nih.gov/pubmed/33831124
http://dx.doi.org/10.1371/journal.pone.0249888
_version_ 1783676164253941760
author Chang, Hailing
Guo, Jiayin
Wei, Zhongqiu
Huang, Zheng
Wang, Chuning
Qiu, Yue
Xu, Xuebin
Zeng, Mei
author_facet Chang, Hailing
Guo, Jiayin
Wei, Zhongqiu
Huang, Zheng
Wang, Chuning
Qiu, Yue
Xu, Xuebin
Zeng, Mei
author_sort Chang, Hailing
collection PubMed
description Diarrhoea remains a major cause of childhood morbidity and mortality worldwide. This study aimed to monitor the aetiology of acute diarrhoea in children in Shanghai. Paediatric outpatients with acute diarrhoea were enrolled in the study from Jan 2015 to Dec 2018. Faecal samples were collected for testing. Enteric bacteria were identified and typed by culture and serotyping, respectively. Enteric viruses were identified by real-time PCR. Enteric pathogens were identified in 1572 (58.4%) of the 2692 enrolled children with acute diarrhoea. Viruses were detected more frequently than bacteria (41.3% versus 25.0%). Nontyphoidal Salmonella spp. (NTS) was the most common (10.3%) bacteria isolated, followed by enteropathogenic Escherichia coli (EPEC) (6.5%), enteroaggregative Escherichia coli (EAEC) (6.2%), Campylobacter spp. (3.6%), enterotoxigenic Escherichia coli (ETEC) (1.1%), Shigella spp. (0.2%), and enterohemorrhagic Escherichia coli (EHEC) (0.1%). Rotavirus was the most common (16.0%) virus detected, followed by norovirus (15.5%), adenovirus (7.2%), sapovirus (3.0%) and astrovirus (2.7%). Rotavirus, norovirus and NTS were the major pathogens responsible for diarrhoea in Shanghainese children. Improving uptake of the rotavirus vaccine and strengthening foodborne-pathogen prevention will aid in reducing the burden of diarrhoeal disease in children in Shanghai.
format Online
Article
Text
id pubmed-8031434
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-80314342021-04-14 Aetiology of acute diarrhoea in children in Shanghai, 2015–2018 Chang, Hailing Guo, Jiayin Wei, Zhongqiu Huang, Zheng Wang, Chuning Qiu, Yue Xu, Xuebin Zeng, Mei PLoS One Research Article Diarrhoea remains a major cause of childhood morbidity and mortality worldwide. This study aimed to monitor the aetiology of acute diarrhoea in children in Shanghai. Paediatric outpatients with acute diarrhoea were enrolled in the study from Jan 2015 to Dec 2018. Faecal samples were collected for testing. Enteric bacteria were identified and typed by culture and serotyping, respectively. Enteric viruses were identified by real-time PCR. Enteric pathogens were identified in 1572 (58.4%) of the 2692 enrolled children with acute diarrhoea. Viruses were detected more frequently than bacteria (41.3% versus 25.0%). Nontyphoidal Salmonella spp. (NTS) was the most common (10.3%) bacteria isolated, followed by enteropathogenic Escherichia coli (EPEC) (6.5%), enteroaggregative Escherichia coli (EAEC) (6.2%), Campylobacter spp. (3.6%), enterotoxigenic Escherichia coli (ETEC) (1.1%), Shigella spp. (0.2%), and enterohemorrhagic Escherichia coli (EHEC) (0.1%). Rotavirus was the most common (16.0%) virus detected, followed by norovirus (15.5%), adenovirus (7.2%), sapovirus (3.0%) and astrovirus (2.7%). Rotavirus, norovirus and NTS were the major pathogens responsible for diarrhoea in Shanghainese children. Improving uptake of the rotavirus vaccine and strengthening foodborne-pathogen prevention will aid in reducing the burden of diarrhoeal disease in children in Shanghai. Public Library of Science 2021-04-08 /pmc/articles/PMC8031434/ /pubmed/33831124 http://dx.doi.org/10.1371/journal.pone.0249888 Text en © 2021 Chang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chang, Hailing
Guo, Jiayin
Wei, Zhongqiu
Huang, Zheng
Wang, Chuning
Qiu, Yue
Xu, Xuebin
Zeng, Mei
Aetiology of acute diarrhoea in children in Shanghai, 2015–2018
title Aetiology of acute diarrhoea in children in Shanghai, 2015–2018
title_full Aetiology of acute diarrhoea in children in Shanghai, 2015–2018
title_fullStr Aetiology of acute diarrhoea in children in Shanghai, 2015–2018
title_full_unstemmed Aetiology of acute diarrhoea in children in Shanghai, 2015–2018
title_short Aetiology of acute diarrhoea in children in Shanghai, 2015–2018
title_sort aetiology of acute diarrhoea in children in shanghai, 2015–2018
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031434/
https://www.ncbi.nlm.nih.gov/pubmed/33831124
http://dx.doi.org/10.1371/journal.pone.0249888
work_keys_str_mv AT changhailing aetiologyofacutediarrhoeainchildreninshanghai20152018
AT guojiayin aetiologyofacutediarrhoeainchildreninshanghai20152018
AT weizhongqiu aetiologyofacutediarrhoeainchildreninshanghai20152018
AT huangzheng aetiologyofacutediarrhoeainchildreninshanghai20152018
AT wangchuning aetiologyofacutediarrhoeainchildreninshanghai20152018
AT qiuyue aetiologyofacutediarrhoeainchildreninshanghai20152018
AT xuxuebin aetiologyofacutediarrhoeainchildreninshanghai20152018
AT zengmei aetiologyofacutediarrhoeainchildreninshanghai20152018