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Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka
End TB strategy by the WHO suggest active screening of high-risk populations for tuberculosis (TB) to improve case detection. Present study generates evidence for the effectiveness of screening patients with diabetes mellitus (DM) for Pulmonary TB (PTB). A study was conducted among 4548 systematical...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031956/ https://www.ncbi.nlm.nih.gov/pubmed/33831095 http://dx.doi.org/10.1371/journal.pone.0249787 |
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author | Hewage, Sumudu Somasundaram, Noel Ratnasamy, Vithiya Ranathunga, Ishara Fernando, Amitha Perera, Indika Perera, Udara Vidanagama, Dhammika Cader, Mizaya Fernando, Poorna Pallewatte, Nirupa Rathnayaka, Lakmal Jayawardhana, Dushani Danansuriya, Manjula Gunawardena, Nalika |
author_facet | Hewage, Sumudu Somasundaram, Noel Ratnasamy, Vithiya Ranathunga, Ishara Fernando, Amitha Perera, Indika Perera, Udara Vidanagama, Dhammika Cader, Mizaya Fernando, Poorna Pallewatte, Nirupa Rathnayaka, Lakmal Jayawardhana, Dushani Danansuriya, Manjula Gunawardena, Nalika |
author_sort | Hewage, Sumudu |
collection | PubMed |
description | End TB strategy by the WHO suggest active screening of high-risk populations for tuberculosis (TB) to improve case detection. Present study generates evidence for the effectiveness of screening patients with diabetes mellitus (DM) for Pulmonary TB (PTB). A study was conducted among 4548 systematically recruited patients over 45 years attending DM clinic at the National Hospital of Sri Lanka. The study units followed an algorithm specifying TB symptom and risk factor screening for all, followed by investigations and clinical assessments for those indicated. Bacteriologically confirmed or clinically diagnosed PTB were presented as proportions with 95% CI. Mean (SD) age was 62·5 (29·1) years. Among patients who completed all indicated steps of algorithm, 3500 (76·9%) were investigated and 127 (2·8%) underwent clinical assessment. Proportion of bacteriologically confirmed PTB patients was 0·1% (n = 6,95%CI = 0·0–0·3%). None were detected clinically. Analysis revealed PTB detection rates among males aged ≥60 years with HbA1c ≥ 8 to be 0·4% (n = 2, 95%CI = 0·0–1·4%). The study concludes that active screening for PTB among all DM patients at clinic settings in Sri Lanka, to be non-effective measure to enhance TB case finding. However, the sub-category of diabetic males with uncontrolled diabetics who are over 60 years of age is recommended as an option to consider for active screening for PTB. |
format | Online Article Text |
id | pubmed-8031956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80319562021-04-15 Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka Hewage, Sumudu Somasundaram, Noel Ratnasamy, Vithiya Ranathunga, Ishara Fernando, Amitha Perera, Indika Perera, Udara Vidanagama, Dhammika Cader, Mizaya Fernando, Poorna Pallewatte, Nirupa Rathnayaka, Lakmal Jayawardhana, Dushani Danansuriya, Manjula Gunawardena, Nalika PLoS One Research Article End TB strategy by the WHO suggest active screening of high-risk populations for tuberculosis (TB) to improve case detection. Present study generates evidence for the effectiveness of screening patients with diabetes mellitus (DM) for Pulmonary TB (PTB). A study was conducted among 4548 systematically recruited patients over 45 years attending DM clinic at the National Hospital of Sri Lanka. The study units followed an algorithm specifying TB symptom and risk factor screening for all, followed by investigations and clinical assessments for those indicated. Bacteriologically confirmed or clinically diagnosed PTB were presented as proportions with 95% CI. Mean (SD) age was 62·5 (29·1) years. Among patients who completed all indicated steps of algorithm, 3500 (76·9%) were investigated and 127 (2·8%) underwent clinical assessment. Proportion of bacteriologically confirmed PTB patients was 0·1% (n = 6,95%CI = 0·0–0·3%). None were detected clinically. Analysis revealed PTB detection rates among males aged ≥60 years with HbA1c ≥ 8 to be 0·4% (n = 2, 95%CI = 0·0–1·4%). The study concludes that active screening for PTB among all DM patients at clinic settings in Sri Lanka, to be non-effective measure to enhance TB case finding. However, the sub-category of diabetic males with uncontrolled diabetics who are over 60 years of age is recommended as an option to consider for active screening for PTB. Public Library of Science 2021-04-08 /pmc/articles/PMC8031956/ /pubmed/33831095 http://dx.doi.org/10.1371/journal.pone.0249787 Text en © 2021 Hewage et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hewage, Sumudu Somasundaram, Noel Ratnasamy, Vithiya Ranathunga, Ishara Fernando, Amitha Perera, Indika Perera, Udara Vidanagama, Dhammika Cader, Mizaya Fernando, Poorna Pallewatte, Nirupa Rathnayaka, Lakmal Jayawardhana, Dushani Danansuriya, Manjula Gunawardena, Nalika Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka |
title | Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka |
title_full | Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka |
title_fullStr | Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka |
title_full_unstemmed | Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka |
title_short | Active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in Sri Lanka |
title_sort | active screening of patients with diabetes mellitus for pulmonary tuberculosis in a tertiary care hospital in sri lanka |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8031956/ https://www.ncbi.nlm.nih.gov/pubmed/33831095 http://dx.doi.org/10.1371/journal.pone.0249787 |
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