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Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma
As the most common histologic subtype of renal cancer, clear cell renal cell carcinoma (ccRCC) poses a serious threat to public health. However, there are no specific molecular-targeted drugs for ccRCC at present. Human ATP-binding cassette (ABC) transporter family plays an important role in homeost...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032227/ https://www.ncbi.nlm.nih.gov/pubmed/33825659 http://dx.doi.org/10.1080/19336950.2021.1909301 |
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author | Meng, Fucheng Xiao, Yafei Xie, Longxiang Liu, Qiao Qian, Keli |
author_facet | Meng, Fucheng Xiao, Yafei Xie, Longxiang Liu, Qiao Qian, Keli |
author_sort | Meng, Fucheng |
collection | PubMed |
description | As the most common histologic subtype of renal cancer, clear cell renal cell carcinoma (ccRCC) poses a serious threat to public health. However, there are no specific molecular-targeted drugs for ccRCC at present. Human ATP-binding cassette (ABC) transporter family plays an important role in homeostasis maintenance. This study aimed to evaluate the potential diagnostic value of ABC genes in ccRCC. A total of 952 samples of ccRCC patients (707) and controls (245) from three different datasets were included for analysis. Receiver operating characteristic analysis and t-test were used to analyze the differential expression of ABC genes in ccRCC patients and control samples at mRNA level during screening and validations. The Cancer Genome Atlas (TCGA-ccRCC) dataset was utilized to investigate the correlation between ABC genes expression and prognostic value in ccRCC. We then investigated the interactions between ABCG1 and proteins in the Comparative Toxicogenomics Database (CTD). Finally, we found that ATP-binding cassette transporter G member 1 (ABCG1) was over-expressed in ccRCC patients compared with healthy samples at mRNA level. Cox regression analysis and Kaplan–Meier analysis showed that ccRCC patients with high ABCG1 expression had better overall survival (OS) than those patients with low expression (hazard ratio (HR) = 0.662, p = 0.007). This study demonstrated that ABCG1 is a potential diagnostic and prognostic biomarker in ccRCC and discussed the molecular mechanisms underlying the relationship between ccRCC and ABCG1, which might provide guidance for better management and treatment of ccRCC in the future. |
format | Online Article Text |
id | pubmed-8032227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-80322272021-04-21 Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma Meng, Fucheng Xiao, Yafei Xie, Longxiang Liu, Qiao Qian, Keli Channels (Austin) Research Paper As the most common histologic subtype of renal cancer, clear cell renal cell carcinoma (ccRCC) poses a serious threat to public health. However, there are no specific molecular-targeted drugs for ccRCC at present. Human ATP-binding cassette (ABC) transporter family plays an important role in homeostasis maintenance. This study aimed to evaluate the potential diagnostic value of ABC genes in ccRCC. A total of 952 samples of ccRCC patients (707) and controls (245) from three different datasets were included for analysis. Receiver operating characteristic analysis and t-test were used to analyze the differential expression of ABC genes in ccRCC patients and control samples at mRNA level during screening and validations. The Cancer Genome Atlas (TCGA-ccRCC) dataset was utilized to investigate the correlation between ABC genes expression and prognostic value in ccRCC. We then investigated the interactions between ABCG1 and proteins in the Comparative Toxicogenomics Database (CTD). Finally, we found that ATP-binding cassette transporter G member 1 (ABCG1) was over-expressed in ccRCC patients compared with healthy samples at mRNA level. Cox regression analysis and Kaplan–Meier analysis showed that ccRCC patients with high ABCG1 expression had better overall survival (OS) than those patients with low expression (hazard ratio (HR) = 0.662, p = 0.007). This study demonstrated that ABCG1 is a potential diagnostic and prognostic biomarker in ccRCC and discussed the molecular mechanisms underlying the relationship between ccRCC and ABCG1, which might provide guidance for better management and treatment of ccRCC in the future. Taylor & Francis 2021-04-07 /pmc/articles/PMC8032227/ /pubmed/33825659 http://dx.doi.org/10.1080/19336950.2021.1909301 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Meng, Fucheng Xiao, Yafei Xie, Longxiang Liu, Qiao Qian, Keli Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma |
title | Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma |
title_full | Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma |
title_fullStr | Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma |
title_full_unstemmed | Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma |
title_short | Diagnostic and prognostic value of ABC transporter family member ABCG1 gene in clear cell renal cell carcinoma |
title_sort | diagnostic and prognostic value of abc transporter family member abcg1 gene in clear cell renal cell carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032227/ https://www.ncbi.nlm.nih.gov/pubmed/33825659 http://dx.doi.org/10.1080/19336950.2021.1909301 |
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