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Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients

Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized...

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Autores principales: Wu, Nannan, Dai, Jia, Guo, Mingquan, Li, Jianhui, Zhou, Xin, Li, Feng, Gao, Yuan, Qu, Hongping, Lu, Hongzhou, Jin, Jing, Li, Tao, Shi, Lei, Wu, Qingguo, Tan, Ruoming, Zhu, Mingli, Yang, Lan, Ling, Yun, Xing, Shunpeng, Zhang, Jianzhong, Yao, Bangxin, Le, Shuai, Gu, Jingmin, Qin, Jinhong, Li, Jie, Cheng, Mengjun, Tan, Demeng, Li, Linlin, Zhang, Yiyuan, Zhu, Zhaoqin, Cai, Jinfeng, Song, Zhigang, Guo, Xiaokui, Chen, Li-Kuang, Zhu, Tongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032346/
https://www.ncbi.nlm.nih.gov/pubmed/33703996
http://dx.doi.org/10.1080/22221751.2021.1902754
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author Wu, Nannan
Dai, Jia
Guo, Mingquan
Li, Jianhui
Zhou, Xin
Li, Feng
Gao, Yuan
Qu, Hongping
Lu, Hongzhou
Jin, Jing
Li, Tao
Shi, Lei
Wu, Qingguo
Tan, Ruoming
Zhu, Mingli
Yang, Lan
Ling, Yun
Xing, Shunpeng
Zhang, Jianzhong
Yao, Bangxin
Le, Shuai
Gu, Jingmin
Qin, Jinhong
Li, Jie
Cheng, Mengjun
Tan, Demeng
Li, Linlin
Zhang, Yiyuan
Zhu, Zhaoqin
Cai, Jinfeng
Song, Zhigang
Guo, Xiaokui
Chen, Li-Kuang
Zhu, Tongyu
author_facet Wu, Nannan
Dai, Jia
Guo, Mingquan
Li, Jianhui
Zhou, Xin
Li, Feng
Gao, Yuan
Qu, Hongping
Lu, Hongzhou
Jin, Jing
Li, Tao
Shi, Lei
Wu, Qingguo
Tan, Ruoming
Zhu, Mingli
Yang, Lan
Ling, Yun
Xing, Shunpeng
Zhang, Jianzhong
Yao, Bangxin
Le, Shuai
Gu, Jingmin
Qin, Jinhong
Li, Jie
Cheng, Mengjun
Tan, Demeng
Li, Linlin
Zhang, Yiyuan
Zhu, Zhaoqin
Cai, Jinfeng
Song, Zhigang
Guo, Xiaokui
Chen, Li-Kuang
Zhu, Tongyu
author_sort Wu, Nannan
collection PubMed
description Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant Acinetobacter baumannii (CRAB) infections to compassionate phage therapy (at 2 successive doses of 10(9) plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients.
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spelling pubmed-80323462021-04-21 Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients Wu, Nannan Dai, Jia Guo, Mingquan Li, Jianhui Zhou, Xin Li, Feng Gao, Yuan Qu, Hongping Lu, Hongzhou Jin, Jing Li, Tao Shi, Lei Wu, Qingguo Tan, Ruoming Zhu, Mingli Yang, Lan Ling, Yun Xing, Shunpeng Zhang, Jianzhong Yao, Bangxin Le, Shuai Gu, Jingmin Qin, Jinhong Li, Jie Cheng, Mengjun Tan, Demeng Li, Linlin Zhang, Yiyuan Zhu, Zhaoqin Cai, Jinfeng Song, Zhigang Guo, Xiaokui Chen, Li-Kuang Zhu, Tongyu Emerg Microbes Infect Research Article Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVID-19 and pulmonary carbapenem-resistant Acinetobacter baumannii (CRAB) infections to compassionate phage therapy (at 2 successive doses of 10(9) plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients. Taylor & Francis 2021-04-07 /pmc/articles/PMC8032346/ /pubmed/33703996 http://dx.doi.org/10.1080/22221751.2021.1902754 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Nannan
Dai, Jia
Guo, Mingquan
Li, Jianhui
Zhou, Xin
Li, Feng
Gao, Yuan
Qu, Hongping
Lu, Hongzhou
Jin, Jing
Li, Tao
Shi, Lei
Wu, Qingguo
Tan, Ruoming
Zhu, Mingli
Yang, Lan
Ling, Yun
Xing, Shunpeng
Zhang, Jianzhong
Yao, Bangxin
Le, Shuai
Gu, Jingmin
Qin, Jinhong
Li, Jie
Cheng, Mengjun
Tan, Demeng
Li, Linlin
Zhang, Yiyuan
Zhu, Zhaoqin
Cai, Jinfeng
Song, Zhigang
Guo, Xiaokui
Chen, Li-Kuang
Zhu, Tongyu
Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
title Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
title_full Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
title_fullStr Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
title_full_unstemmed Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
title_short Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients
title_sort pre-optimized phage therapy on secondary acinetobacter baumannii infection in four critical covid-19 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032346/
https://www.ncbi.nlm.nih.gov/pubmed/33703996
http://dx.doi.org/10.1080/22221751.2021.1902754
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