Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost gene hours after stimulation. Using mouse model...

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Detalles Bibliográficos
Autores principales: Gould, Nicole R, Williams, Katrina M, Joca, Humberto C, Torre, Olivia M, Lyons, James S, Leser, Jenna M, Srikanth, Manasa P, Hughes, Marcus, Khairallah, Ramzi J, Feldman, Ricardo A, Ward, Christopher W, Stains, Joseph P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032393/
https://www.ncbi.nlm.nih.gov/pubmed/33779549
http://dx.doi.org/10.7554/eLife.64393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032393/
https://www.ncbi.nlm.nih.gov/pubmed/33779549
http://dx.doi.org/10.7554/eLife.64393

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