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In silico investigation of potential small molecule inhibitors of the SARS-CoV-2 nsp10-nsp16 methyltransferase complex

The COVID-19 pandemic caused by SARS-CoV-2 has resulted in an international health emergency. The SARS-CoV-2 nsp16 is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase, and with its cofactor nsp10, is responsible for RNA cap formation. This study aimed to identify small molecules binding...

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Detalles Bibliográficos
Autores principales:	Liang, Julia, Pitsillou, Eleni, Burbury, Lucy, Hung, Andrew, Karagiannis, Tom C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032478/ https://www.ncbi.nlm.nih.gov/pubmed/33850334 http://dx.doi.org/10.1016/j.cplett.2021.138618

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