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Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation
Propofol, 2,6-diisopropylphenol, is a short-acting intravenous sedative agent used in adults and children. Current studies show its various antimicrobial as well as anti-inflammatory effects. Dengue virus (DENV) is an emerging infectious pathogen transmitted by mosquitoes that causes mild dengue fev...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032536/ https://www.ncbi.nlm.nih.gov/pubmed/33869639 http://dx.doi.org/10.1155/2021/6680913 |
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author | Shen, Ting-Jing Chen, Chia-Ling Jhan, Ming-Kai Tseng, Po-Chun Satria, Rahmat Dani Hsing, Chung-Hsi Lin, Chiou-Feng |
author_facet | Shen, Ting-Jing Chen, Chia-Ling Jhan, Ming-Kai Tseng, Po-Chun Satria, Rahmat Dani Hsing, Chung-Hsi Lin, Chiou-Feng |
author_sort | Shen, Ting-Jing |
collection | PubMed |
description | Propofol, 2,6-diisopropylphenol, is a short-acting intravenous sedative agent used in adults and children. Current studies show its various antimicrobial as well as anti-inflammatory effects. Dengue virus (DENV) is an emerging infectious pathogen transmitted by mosquitoes that causes mild dengue fever and progressive severe dengue diseases. In the absence of safe vaccines and antiviral agents, adjuvant treatments and supportive care are generally administered. This study investigated the antiviral effects of propofol against DENV infection and cellular inflammation by using an in vitro cell model. Treatment with propofol significantly inhibited DENV release 24 h postinfection in BHK-21 cells. Furthermore, it also blocked viral protein expression independent of the translational blockade. Propofol neither caused inhibitory effects on endosomal acidification nor prevented dsRNA replication. Either the proinflammatory TNF-α or the antiviral STAT1 signaling was reduced by propofol treatment. These results provide evidence to show the potential antiviral effects of the sedative propofol against DENV infection and cellular inflammation. |
format | Online Article Text |
id | pubmed-8032536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80325362021-04-16 Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation Shen, Ting-Jing Chen, Chia-Ling Jhan, Ming-Kai Tseng, Po-Chun Satria, Rahmat Dani Hsing, Chung-Hsi Lin, Chiou-Feng J Immunol Res Research Article Propofol, 2,6-diisopropylphenol, is a short-acting intravenous sedative agent used in adults and children. Current studies show its various antimicrobial as well as anti-inflammatory effects. Dengue virus (DENV) is an emerging infectious pathogen transmitted by mosquitoes that causes mild dengue fever and progressive severe dengue diseases. In the absence of safe vaccines and antiviral agents, adjuvant treatments and supportive care are generally administered. This study investigated the antiviral effects of propofol against DENV infection and cellular inflammation by using an in vitro cell model. Treatment with propofol significantly inhibited DENV release 24 h postinfection in BHK-21 cells. Furthermore, it also blocked viral protein expression independent of the translational blockade. Propofol neither caused inhibitory effects on endosomal acidification nor prevented dsRNA replication. Either the proinflammatory TNF-α or the antiviral STAT1 signaling was reduced by propofol treatment. These results provide evidence to show the potential antiviral effects of the sedative propofol against DENV infection and cellular inflammation. Hindawi 2021-03-31 /pmc/articles/PMC8032536/ /pubmed/33869639 http://dx.doi.org/10.1155/2021/6680913 Text en Copyright © 2021 Ting-Jing Shen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shen, Ting-Jing Chen, Chia-Ling Jhan, Ming-Kai Tseng, Po-Chun Satria, Rahmat Dani Hsing, Chung-Hsi Lin, Chiou-Feng Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation |
title | Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation |
title_full | Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation |
title_fullStr | Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation |
title_full_unstemmed | Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation |
title_short | Antiviral Efficacy of the Anesthetic Propofol against Dengue Virus Infection and Cellular Inflammation |
title_sort | antiviral efficacy of the anesthetic propofol against dengue virus infection and cellular inflammation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032536/ https://www.ncbi.nlm.nih.gov/pubmed/33869639 http://dx.doi.org/10.1155/2021/6680913 |
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