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Targeting Nanostrategies for Imaging of Atherosclerosis
Despite the progress in cardiovascular research, atherosclerosis still represents the main cause of death worldwide. Clinically, the diagnosis of Atherosclerotic Cardiovascular Disease (ASCVD) relies on imaging methodologies including X-ray angiography and computed tomography (CT), which however sti...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032543/ https://www.ncbi.nlm.nih.gov/pubmed/33880112 http://dx.doi.org/10.1155/2021/6664471 |
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author | Costagliola di Polidoro, Angela Grassia, Agnese De Sarno, Francesca Bevilacqua, Paolo Mollo, Valentina Romano, Eugenia Di Taranto, Maria Donata Fortunato, Giuliana Bracale, Umberto Marcello Tramontano, Liberatore Diomaiuti, Tommaso Claudio Torino, Enza |
author_facet | Costagliola di Polidoro, Angela Grassia, Agnese De Sarno, Francesca Bevilacqua, Paolo Mollo, Valentina Romano, Eugenia Di Taranto, Maria Donata Fortunato, Giuliana Bracale, Umberto Marcello Tramontano, Liberatore Diomaiuti, Tommaso Claudio Torino, Enza |
author_sort | Costagliola di Polidoro, Angela |
collection | PubMed |
description | Despite the progress in cardiovascular research, atherosclerosis still represents the main cause of death worldwide. Clinically, the diagnosis of Atherosclerotic Cardiovascular Disease (ASCVD) relies on imaging methodologies including X-ray angiography and computed tomography (CT), which however still fails in the identification of patients at high risk of plaque rupture, the main cause of severe clinical events as stroke and heart attack. Magnetic resonance imaging, which is characterized by very high spatial resolution, could provide a better characterization of atherosclerotic plaque (AP) anatomy and composition, aiding in the identification of “vulnerable” plaques. In this context, hydrogel matrices, which have been demonstrated able to boost relaxometric properties of Gd-based contrast agents (CAs) by the effect of Hydrodenticity, represent a valuable tool towards the precision imaging of ASCVD improving the performance of this class of CAs while reducing systemic toxicity. In particular, hydrogel nanoparticles encapsulating Gd-DTPA can further contribute to providing CA-specific accumulation in the AP by nanoparticle surface decoration triggering an active targeting of the AP with the overall effect of allowing an earlier and more accurate diagnosis. In this work, we tested crosslinked Hyaluronic Acid Nanoparticles (cHANPs) in the complex environment of human atherosclerotic plaque. In addition, the surface of cHANPs was decorated with the antibody anti-CD36 (Ab36-cHANPs) for the active targeting of AP-associated macrophages. Results demonstrate that the Hydrodenticity of cHANPs and Ab36-cHANPs is preserved in this complex system and, preliminarily, that interaction of these probes with the AP is present. |
format | Online Article Text |
id | pubmed-8032543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80325432021-04-19 Targeting Nanostrategies for Imaging of Atherosclerosis Costagliola di Polidoro, Angela Grassia, Agnese De Sarno, Francesca Bevilacqua, Paolo Mollo, Valentina Romano, Eugenia Di Taranto, Maria Donata Fortunato, Giuliana Bracale, Umberto Marcello Tramontano, Liberatore Diomaiuti, Tommaso Claudio Torino, Enza Contrast Media Mol Imaging Research Article Despite the progress in cardiovascular research, atherosclerosis still represents the main cause of death worldwide. Clinically, the diagnosis of Atherosclerotic Cardiovascular Disease (ASCVD) relies on imaging methodologies including X-ray angiography and computed tomography (CT), which however still fails in the identification of patients at high risk of plaque rupture, the main cause of severe clinical events as stroke and heart attack. Magnetic resonance imaging, which is characterized by very high spatial resolution, could provide a better characterization of atherosclerotic plaque (AP) anatomy and composition, aiding in the identification of “vulnerable” plaques. In this context, hydrogel matrices, which have been demonstrated able to boost relaxometric properties of Gd-based contrast agents (CAs) by the effect of Hydrodenticity, represent a valuable tool towards the precision imaging of ASCVD improving the performance of this class of CAs while reducing systemic toxicity. In particular, hydrogel nanoparticles encapsulating Gd-DTPA can further contribute to providing CA-specific accumulation in the AP by nanoparticle surface decoration triggering an active targeting of the AP with the overall effect of allowing an earlier and more accurate diagnosis. In this work, we tested crosslinked Hyaluronic Acid Nanoparticles (cHANPs) in the complex environment of human atherosclerotic plaque. In addition, the surface of cHANPs was decorated with the antibody anti-CD36 (Ab36-cHANPs) for the active targeting of AP-associated macrophages. Results demonstrate that the Hydrodenticity of cHANPs and Ab36-cHANPs is preserved in this complex system and, preliminarily, that interaction of these probes with the AP is present. Hindawi 2021-03-31 /pmc/articles/PMC8032543/ /pubmed/33880112 http://dx.doi.org/10.1155/2021/6664471 Text en Copyright © 2021 Angela Costagliola di Polidoro et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Costagliola di Polidoro, Angela Grassia, Agnese De Sarno, Francesca Bevilacqua, Paolo Mollo, Valentina Romano, Eugenia Di Taranto, Maria Donata Fortunato, Giuliana Bracale, Umberto Marcello Tramontano, Liberatore Diomaiuti, Tommaso Claudio Torino, Enza Targeting Nanostrategies for Imaging of Atherosclerosis |
title | Targeting Nanostrategies for Imaging of Atherosclerosis |
title_full | Targeting Nanostrategies for Imaging of Atherosclerosis |
title_fullStr | Targeting Nanostrategies for Imaging of Atherosclerosis |
title_full_unstemmed | Targeting Nanostrategies for Imaging of Atherosclerosis |
title_short | Targeting Nanostrategies for Imaging of Atherosclerosis |
title_sort | targeting nanostrategies for imaging of atherosclerosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032543/ https://www.ncbi.nlm.nih.gov/pubmed/33880112 http://dx.doi.org/10.1155/2021/6664471 |
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