Control of endothelial quiescence by FOXO-regulated metabolites

Endothelial cells (ECs) adapt their metabolism to enable the growth of new blood vessels, but little is known how ECs regulate metabolism to adopt a quiescent state. Here, we show that the metabolite S-2-hydroxyglutarate (S-2HG) plays a crucial role in the regulation of endothelial quiescence. We fi...

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Detalles Bibliográficos
Autores principales: Andrade, Jorge, Shi, Chenyue, Costa, Ana S. H., Choi, Jeongwoon, Kim, Jaeryung, Doddaballapur, Anuradha, Sugino, Toshiya, Ong, Yu Ting, Castro, Marco, Zimmermann, Barbara, Kaulich, Manuel, Guenther, Stefan, Wilhelm, Kerstin, Kubota, Yoshiaki, Braun, Thomas, Koh, Gou Young, Grosso, Ana Rita, Frezza, Christian, Potente, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032556/
https://www.ncbi.nlm.nih.gov/pubmed/33795871
http://dx.doi.org/10.1038/s41556-021-00637-6

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