An open-label, positron emission tomography study of the striatal D(2)/D(3) receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants

PURPOSE: The aim of this Phase 1, open-label, positron emission tomography (PET) study was to determine the degree of striatal D(2)/D(3) receptor occupancy induced by the serotonin–dopamine activity modulator, brexpiprazole, at different single dose levels in the range 0.25–6 mg. METHODS: Occupancy...

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Detalles Bibliográficos
Autores principales: Wong, Dean F., Raoufinia, Arash, Bricmont, Patricia, Brašić, James R., McQuade, Robert D., Forbes, Robert A., Kikuchi, Tetsuro, Kuwabara, Hiroto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032567/
https://www.ncbi.nlm.nih.gov/pubmed/33196868
http://dx.doi.org/10.1007/s00228-020-03021-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032567/
https://www.ncbi.nlm.nih.gov/pubmed/33196868
http://dx.doi.org/10.1007/s00228-020-03021-9

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