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Normal fat mass cannot be reliably estimated in typical pharmacokinetic studies
PURPOSE: An influential covariate for pharmacokinetics is (body) size. Recently, the method of estimation of normal fat mass (NFM) has been advocated. Here, the relative contribution of fat mass, estimated as a fraction fat (Ffat), is used to explain differences in pharmacokinetic parameters. This c...
Autores principales: | Wasmann, Roeland E., Svensson, Elin M., Schalkwijk, Stein J., Brüggemann, Roger J., ter Heine, Rob |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032617/ https://www.ncbi.nlm.nih.gov/pubmed/33205282 http://dx.doi.org/10.1007/s00228-020-03042-4 |
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