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Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro–in vivo extrapolation

Amiodarone is an antiarrhythmic agent inducing adverse effects on the nervous system, among others. We applied physiologically based pharmacokinetic (PBPK) modeling combined with benchmark dose modeling to predict, based on published in vitro data, the in vivo dose of amiodarone which may lead to ad...

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Detalles Bibliográficos
Autores principales:	Algharably, Engi Abd el-Hady, Di Consiglio, Emma, Testai, Emanuela, Kreutz, Reinhold, Gundert-Remy, Ursula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032623/ https://www.ncbi.nlm.nih.gov/pubmed/33606068 http://dx.doi.org/10.1007/s00204-021-02989-2

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