Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry

Organophosphate pesticides (OPs) are known to inhibit acetylcholine esterase (AChE), a critical effect used to establish health-based guidance values. This study developed a combined in vitro–in silico approach to predict AChE inhibition by the OP profenofos in rats and humans. A physiologically bas...

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Detalles Bibliográficos
Autores principales: Omwenga, Isaac, Zhao, Shensheng, Kanja, Laetitia, Mol, Hans, Rietjens, Ivonne M. C. M., Louisse, Jochem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032624/
https://www.ncbi.nlm.nih.gov/pubmed/33651127
http://dx.doi.org/10.1007/s00204-021-03004-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032624/
https://www.ncbi.nlm.nih.gov/pubmed/33651127
http://dx.doi.org/10.1007/s00204-021-03004-4

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