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Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers

Mitochondrial DNA (mtDNA) is highly polymorphic and encodes 13 proteins which are critical to the production of ATP via oxidative phosphorylation. As mtDNA is maternally inherited and undergoes negligible recombination, acquired mutations have subdivided the human population into several discrete ha...

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Detalles Bibliográficos
Autores principales:	Ball, Amy L., Bloch, Katarzyna M., Rainbow, Lucille, Liu, Xuan, Kenny, John, Lyon, Jonathan J., Gregory, Richard, Alfirevic, Ana, Chadwick, Amy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Toxicogenomics and Omics Technologies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032628/ https://www.ncbi.nlm.nih.gov/pubmed/33585966 http://dx.doi.org/10.1007/s00204-021-02988-3

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