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Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032711/ https://www.ncbi.nlm.nih.gov/pubmed/33833304 http://dx.doi.org/10.1038/s41598-021-87045-w |
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author | Cerveira de Baumont, Angelica Hoffmann, Mauricio Scopel Bortoluzzi, Andressa Fries, Gabriel R. Lavandoski, Patrícia Grun, Lucas K. Guimarães, Luciano S. P. Guma, Fátima T. C. R. Salum, Giovanni Abrahão Barbé-Tuana, Florencia M. Manfro, Gisele G. |
author_facet | Cerveira de Baumont, Angelica Hoffmann, Mauricio Scopel Bortoluzzi, Andressa Fries, Gabriel R. Lavandoski, Patrícia Grun, Lucas K. Guimarães, Luciano S. P. Guma, Fátima T. C. R. Salum, Giovanni Abrahão Barbé-Tuana, Florencia M. Manfro, Gisele G. |
author_sort | Cerveira de Baumont, Angelica |
collection | PubMed |
description | Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life. |
format | Online Article Text |
id | pubmed-8032711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80327112021-04-09 Telomere length and epigenetic age acceleration in adolescents with anxiety disorders Cerveira de Baumont, Angelica Hoffmann, Mauricio Scopel Bortoluzzi, Andressa Fries, Gabriel R. Lavandoski, Patrícia Grun, Lucas K. Guimarães, Luciano S. P. Guma, Fátima T. C. R. Salum, Giovanni Abrahão Barbé-Tuana, Florencia M. Manfro, Gisele G. Sci Rep Article Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life. Nature Publishing Group UK 2021-04-08 /pmc/articles/PMC8032711/ /pubmed/33833304 http://dx.doi.org/10.1038/s41598-021-87045-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Cerveira de Baumont, Angelica Hoffmann, Mauricio Scopel Bortoluzzi, Andressa Fries, Gabriel R. Lavandoski, Patrícia Grun, Lucas K. Guimarães, Luciano S. P. Guma, Fátima T. C. R. Salum, Giovanni Abrahão Barbé-Tuana, Florencia M. Manfro, Gisele G. Telomere length and epigenetic age acceleration in adolescents with anxiety disorders |
title | Telomere length and epigenetic age acceleration in adolescents with anxiety disorders |
title_full | Telomere length and epigenetic age acceleration in adolescents with anxiety disorders |
title_fullStr | Telomere length and epigenetic age acceleration in adolescents with anxiety disorders |
title_full_unstemmed | Telomere length and epigenetic age acceleration in adolescents with anxiety disorders |
title_short | Telomere length and epigenetic age acceleration in adolescents with anxiety disorders |
title_sort | telomere length and epigenetic age acceleration in adolescents with anxiety disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032711/ https://www.ncbi.nlm.nih.gov/pubmed/33833304 http://dx.doi.org/10.1038/s41598-021-87045-w |
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