Cargando…
Spontaneous and deliberate creative cognition during and after psilocybin exposure
Creativity is an essential cognitive ability linked to all areas of our everyday functioning. Thus, finding a way to enhance it is of broad interest. A large number of anecdotal reports suggest that the consumption of psychedelic drugs can enhance creative thinking; however, scientific evidence is l...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032715/ https://www.ncbi.nlm.nih.gov/pubmed/33833225 http://dx.doi.org/10.1038/s41398-021-01335-5 |
_version_ | 1783676267047944192 |
---|---|
author | Mason, N. L. Kuypers, K. P. C. Reckweg, J. T. Müller, F. Tse, D. H. Y. Da Rios, B. Toennes, S. W. Stiers, P. Feilding, A. Ramaekers, J. G. |
author_facet | Mason, N. L. Kuypers, K. P. C. Reckweg, J. T. Müller, F. Tse, D. H. Y. Da Rios, B. Toennes, S. W. Stiers, P. Feilding, A. Ramaekers, J. G. |
author_sort | Mason, N. L. |
collection | PubMed |
description | Creativity is an essential cognitive ability linked to all areas of our everyday functioning. Thus, finding a way to enhance it is of broad interest. A large number of anecdotal reports suggest that the consumption of psychedelic drugs can enhance creative thinking; however, scientific evidence is lacking. Following a double-blind, placebo-controlled, parallel-group design, we demonstrated that psilocybin (0.17 mg/kg) induced a time- and construct-related differentiation of effects on creative thinking. Acutely, psilocybin increased ratings of (spontaneous) creative insights, while decreasing (deliberate) task-based creativity. Seven days after psilocybin, number of novel ideas increased. Furthermore, we utilized an ultrahigh field multimodal brain imaging approach, and found that acute and persisting effects were predicted by within- and between-network connectivity of the default mode network. Findings add some support to historical claims that psychedelics can influence aspects of the creative process, potentially indicating them as a tool to investigate creativity and subsequent underlying neural mechanisms. Trial NL6007; psilocybin as a tool for enhanced cognitive flexibility; https://www.trialregister.nl/trial/6007. |
format | Online Article Text |
id | pubmed-8032715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80327152021-04-27 Spontaneous and deliberate creative cognition during and after psilocybin exposure Mason, N. L. Kuypers, K. P. C. Reckweg, J. T. Müller, F. Tse, D. H. Y. Da Rios, B. Toennes, S. W. Stiers, P. Feilding, A. Ramaekers, J. G. Transl Psychiatry Article Creativity is an essential cognitive ability linked to all areas of our everyday functioning. Thus, finding a way to enhance it is of broad interest. A large number of anecdotal reports suggest that the consumption of psychedelic drugs can enhance creative thinking; however, scientific evidence is lacking. Following a double-blind, placebo-controlled, parallel-group design, we demonstrated that psilocybin (0.17 mg/kg) induced a time- and construct-related differentiation of effects on creative thinking. Acutely, psilocybin increased ratings of (spontaneous) creative insights, while decreasing (deliberate) task-based creativity. Seven days after psilocybin, number of novel ideas increased. Furthermore, we utilized an ultrahigh field multimodal brain imaging approach, and found that acute and persisting effects were predicted by within- and between-network connectivity of the default mode network. Findings add some support to historical claims that psychedelics can influence aspects of the creative process, potentially indicating them as a tool to investigate creativity and subsequent underlying neural mechanisms. Trial NL6007; psilocybin as a tool for enhanced cognitive flexibility; https://www.trialregister.nl/trial/6007. Nature Publishing Group UK 2021-04-08 /pmc/articles/PMC8032715/ /pubmed/33833225 http://dx.doi.org/10.1038/s41398-021-01335-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Mason, N. L. Kuypers, K. P. C. Reckweg, J. T. Müller, F. Tse, D. H. Y. Da Rios, B. Toennes, S. W. Stiers, P. Feilding, A. Ramaekers, J. G. Spontaneous and deliberate creative cognition during and after psilocybin exposure |
title | Spontaneous and deliberate creative cognition during and after psilocybin exposure |
title_full | Spontaneous and deliberate creative cognition during and after psilocybin exposure |
title_fullStr | Spontaneous and deliberate creative cognition during and after psilocybin exposure |
title_full_unstemmed | Spontaneous and deliberate creative cognition during and after psilocybin exposure |
title_short | Spontaneous and deliberate creative cognition during and after psilocybin exposure |
title_sort | spontaneous and deliberate creative cognition during and after psilocybin exposure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032715/ https://www.ncbi.nlm.nih.gov/pubmed/33833225 http://dx.doi.org/10.1038/s41398-021-01335-5 |
work_keys_str_mv | AT masonnl spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT kuyperskpc spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT reckwegjt spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT mullerf spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT tsedhy spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT dariosb spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT toennessw spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT stiersp spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT feildinga spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure AT ramaekersjg spontaneousanddeliberatecreativecognitionduringandafterpsilocybinexposure |