Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction

Mitochondrial diseases impair oxidative phosphorylation and ATP production, while effective treatment is still lacking. Defective complex III is associated with a highly variable clinical spectrum. We show that pyocyanin, a bacterial redox cycler, can replace the redox functions of complex III, acti...

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Detalles Bibliográficos
Autores principales: Peruzzo, Roberta, Corrà, Samantha, Costa, Roberto, Brischigliaro, Michele, Varanita, Tatiana, Biasutto, Lucia, Rampazzo, Chiara, Ghezzi, Daniele, Leanza, Luigi, Zoratti, Mario, Zeviani, Massimo, De Pittà, Cristiano, Viscomi, Carlo, Costa, Rodolfo, Szabò, Ildikò
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032734/
https://www.ncbi.nlm.nih.gov/pubmed/33833234
http://dx.doi.org/10.1038/s41467-021-22062-x

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