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Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fr...

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Autores principales: Xie, An, Wu, Qiuxia, Yang, Winson Fu Zun, Qi, Chang, Liao, Yanhui, Wang, Xuyi, Hao, Wei, Tang, Yi-Yuan, Liu, Jianbin, Liu, Tieqiao, Tang, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032776/
https://www.ncbi.nlm.nih.gov/pubmed/33833282
http://dx.doi.org/10.1038/s41598-021-87185-z
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author Xie, An
Wu, Qiuxia
Yang, Winson Fu Zun
Qi, Chang
Liao, Yanhui
Wang, Xuyi
Hao, Wei
Tang, Yi-Yuan
Liu, Jianbin
Liu, Tieqiao
Tang, Jinsong
author_facet Xie, An
Wu, Qiuxia
Yang, Winson Fu Zun
Qi, Chang
Liao, Yanhui
Wang, Xuyi
Hao, Wei
Tang, Yi-Yuan
Liu, Jianbin
Liu, Tieqiao
Tang, Jinsong
author_sort Xie, An
collection PubMed
description Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (n = 70) and healthy controls (HCs) (n = 84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence.
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spelling pubmed-80327762021-04-09 Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users Xie, An Wu, Qiuxia Yang, Winson Fu Zun Qi, Chang Liao, Yanhui Wang, Xuyi Hao, Wei Tang, Yi-Yuan Liu, Jianbin Liu, Tieqiao Tang, Jinsong Sci Rep Article Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (n = 70) and healthy controls (HCs) (n = 84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence. Nature Publishing Group UK 2021-04-08 /pmc/articles/PMC8032776/ /pubmed/33833282 http://dx.doi.org/10.1038/s41598-021-87185-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author (s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Xie, An
Wu, Qiuxia
Yang, Winson Fu Zun
Qi, Chang
Liao, Yanhui
Wang, Xuyi
Hao, Wei
Tang, Yi-Yuan
Liu, Jianbin
Liu, Tieqiao
Tang, Jinsong
Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_full Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_fullStr Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_full_unstemmed Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_short Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
title_sort altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032776/
https://www.ncbi.nlm.nih.gov/pubmed/33833282
http://dx.doi.org/10.1038/s41598-021-87185-z
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