Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites

Smc5/6 is essential for genome structural integrity by yet unknown mechanisms. Here we find that Smc5/6 co-localizes with the DNA crossed-strand processing complex Sgs1-Top3-Rmi1 (STR) at genomic regions known as natural pausing sites (NPSs) where it facilitates Top3 retention. Individual depletions...

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Detalles Bibliográficos
Autores principales: Agashe, Sumedha, Joseph, Chinnu Rose, Reyes, Teresa Anne Clarisse, Menolfi, Demis, Giannattasio, Michele, Waizenegger, Anja, Szakal, Barnabas, Branzei, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032827/
https://www.ncbi.nlm.nih.gov/pubmed/33833229
http://dx.doi.org/10.1038/s41467-021-22217-w

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