Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides

A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good an...

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Autores principales: Chen, Meihang, Zhang, Xun, Lu, Daowang, Luo, Hairong, Zhou, Zengyan, Qin, Xufeng, Wu, Wenneng, Zhang, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032861/
https://www.ncbi.nlm.nih.gov/pubmed/33842434
http://dx.doi.org/10.3389/fchem.2021.645876
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author Chen, Meihang
Zhang, Xun
Lu, Daowang
Luo, Hairong
Zhou, Zengyan
Qin, Xufeng
Wu, Wenneng
Zhang, Guoping
author_facet Chen, Meihang
Zhang, Xun
Lu, Daowang
Luo, Hairong
Zhou, Zengyan
Qin, Xufeng
Wu, Wenneng
Zhang, Guoping
author_sort Chen, Meihang
collection PubMed
description A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good antifungal activities. Especially, compounds 4i showed higher bioactivities against Phytophthora infestans (P. infestans), with the EC(50) values of 3.43, than that of Dimethomorph (5.52 μg/ml). In addition, the target compounds exhibited moderate to poor antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas campestris pv. citri (Xcc).
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spelling pubmed-80328612021-04-10 Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides Chen, Meihang Zhang, Xun Lu, Daowang Luo, Hairong Zhou, Zengyan Qin, Xufeng Wu, Wenneng Zhang, Guoping Front Chem Chemistry A series of novel 1,3,4-thiadiazole derivatives of glucosides were synthesized by the starting materials d-glucose and 5-amino-1,3,4-thiadiazole-2-thiol in good yields with employing a convergent synthetic route. The results of bioactivities showed that some of the target compounds exhibited good antifungal activities. Especially, compounds 4i showed higher bioactivities against Phytophthora infestans (P. infestans), with the EC(50) values of 3.43, than that of Dimethomorph (5.52 μg/ml). In addition, the target compounds exhibited moderate to poor antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas campestris pv. citri (Xcc). Frontiers Media S.A. 2021-03-26 /pmc/articles/PMC8032861/ /pubmed/33842434 http://dx.doi.org/10.3389/fchem.2021.645876 Text en Copyright © 2021 Chen, Zhang, Lu, Luo, Zhou, Qin, Wu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Chen, Meihang
Zhang, Xun
Lu, Daowang
Luo, Hairong
Zhou, Zengyan
Qin, Xufeng
Wu, Wenneng
Zhang, Guoping
Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
title Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
title_full Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
title_fullStr Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
title_full_unstemmed Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
title_short Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
title_sort synthesis and bioactivities of novel 1,3,4-thiadiazole derivatives of glucosides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032861/
https://www.ncbi.nlm.nih.gov/pubmed/33842434
http://dx.doi.org/10.3389/fchem.2021.645876
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