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Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder
Cognitive reappraisal is an emotion regulation strategy to reduce the impact of affective stimuli. This regulation could be incomplete in patients with functional neurologic disorder (FND) resulting in an overflowing emotional stimulation perpetuating symptoms in FND patients. Here we employed funct...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032865/ https://www.ncbi.nlm.nih.gov/pubmed/33841199 http://dx.doi.org/10.3389/fpsyt.2021.613156 |
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author | Hassa, Thomas Spiteri, Stefan Schmidt, Roger Merkel, Christian Schoenfeld, Mircea Ariel |
author_facet | Hassa, Thomas Spiteri, Stefan Schmidt, Roger Merkel, Christian Schoenfeld, Mircea Ariel |
author_sort | Hassa, Thomas |
collection | PubMed |
description | Cognitive reappraisal is an emotion regulation strategy to reduce the impact of affective stimuli. This regulation could be incomplete in patients with functional neurologic disorder (FND) resulting in an overflowing emotional stimulation perpetuating symptoms in FND patients. Here we employed functional MRI to study cognitive reappraisal in FND. A total of 24 FND patients and 24 healthy controls employed cognitive reappraisal while seeing emotional visual stimuli in the scanner. The Symptom Checklist-90-R (SCL-90-R) was used to evaluate concomitant psychopathologies of the patients. During cognitive reappraisal of negative IAPS images FND patients show an increased activation of the right amygdala compared to normal controls. We found no evidence of downregulation in the amygdala during reappraisal neither in the patients nor in the control group. The valence and arousal ratings of the IAPS images were similar across groups. However, a subgroup of patients showed a significant higher account of extreme low ratings for arousal for negative images. These low ratings correlated inversely with the item “anxiety” of the SCL-90-R. The increased activation of the amygdala during cognitive reappraisal suggests altered processing of emotional stimuli in this region in FND patients. |
format | Online Article Text |
id | pubmed-8032865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80328652021-04-10 Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder Hassa, Thomas Spiteri, Stefan Schmidt, Roger Merkel, Christian Schoenfeld, Mircea Ariel Front Psychiatry Psychiatry Cognitive reappraisal is an emotion regulation strategy to reduce the impact of affective stimuli. This regulation could be incomplete in patients with functional neurologic disorder (FND) resulting in an overflowing emotional stimulation perpetuating symptoms in FND patients. Here we employed functional MRI to study cognitive reappraisal in FND. A total of 24 FND patients and 24 healthy controls employed cognitive reappraisal while seeing emotional visual stimuli in the scanner. The Symptom Checklist-90-R (SCL-90-R) was used to evaluate concomitant psychopathologies of the patients. During cognitive reappraisal of negative IAPS images FND patients show an increased activation of the right amygdala compared to normal controls. We found no evidence of downregulation in the amygdala during reappraisal neither in the patients nor in the control group. The valence and arousal ratings of the IAPS images were similar across groups. However, a subgroup of patients showed a significant higher account of extreme low ratings for arousal for negative images. These low ratings correlated inversely with the item “anxiety” of the SCL-90-R. The increased activation of the amygdala during cognitive reappraisal suggests altered processing of emotional stimuli in this region in FND patients. Frontiers Media S.A. 2021-03-26 /pmc/articles/PMC8032865/ /pubmed/33841199 http://dx.doi.org/10.3389/fpsyt.2021.613156 Text en Copyright © 2021 Hassa, Spiteri, Schmidt, Merkel and Schoenfeld. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Hassa, Thomas Spiteri, Stefan Schmidt, Roger Merkel, Christian Schoenfeld, Mircea Ariel Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder |
title | Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder |
title_full | Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder |
title_fullStr | Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder |
title_full_unstemmed | Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder |
title_short | Increased Amygdala Activity Associated With Cognitive Reappraisal Strategy in Functional Neurologic Disorder |
title_sort | increased amygdala activity associated with cognitive reappraisal strategy in functional neurologic disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032865/ https://www.ncbi.nlm.nih.gov/pubmed/33841199 http://dx.doi.org/10.3389/fpsyt.2021.613156 |
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