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Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies

Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are classified as type B adverse drug reactions, and are severe, potentially fatal rare disorders. However, the pathogenesis of SJS/TEN is not fully understood. The onset of SJS/TEN is triggered by the immune system in response to ant...

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Detalles Bibliográficos
Autores principales: Imatoh, Takuya, Saito, Yoshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032874/
https://www.ncbi.nlm.nih.gov/pubmed/33842508
http://dx.doi.org/10.3389/fmed.2021.644871
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author Imatoh, Takuya
Saito, Yoshiro
author_facet Imatoh, Takuya
Saito, Yoshiro
author_sort Imatoh, Takuya
collection PubMed
description Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are classified as type B adverse drug reactions, and are severe, potentially fatal rare disorders. However, the pathogenesis of SJS/TEN is not fully understood. The onset of SJS/TEN is triggered by the immune system in response to antigens with or by drugs. As activation of the immune system is important, infection could be a risk factor for the onset of SJS/TEN. Based on the hypothesis that infections induce the onset of SJS/TEN, we conducted pharmacoepidemiological investigations using two spontaneous adverse drug reaction reporting databases (Japanese Adverse Drug Event Report database and Food and Drug Administration Adverse Event Reporting System) and Japanese medical information database. These data suggest that infection could be a risk factor for the development of SJS/TEN. In this mini-review, we discuss the association between infection and the development of SJS/TEN.
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spelling pubmed-80328742021-04-10 Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies Imatoh, Takuya Saito, Yoshiro Front Med (Lausanne) Medicine Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are classified as type B adverse drug reactions, and are severe, potentially fatal rare disorders. However, the pathogenesis of SJS/TEN is not fully understood. The onset of SJS/TEN is triggered by the immune system in response to antigens with or by drugs. As activation of the immune system is important, infection could be a risk factor for the onset of SJS/TEN. Based on the hypothesis that infections induce the onset of SJS/TEN, we conducted pharmacoepidemiological investigations using two spontaneous adverse drug reaction reporting databases (Japanese Adverse Drug Event Report database and Food and Drug Administration Adverse Event Reporting System) and Japanese medical information database. These data suggest that infection could be a risk factor for the development of SJS/TEN. In this mini-review, we discuss the association between infection and the development of SJS/TEN. Frontiers Media S.A. 2021-03-26 /pmc/articles/PMC8032874/ /pubmed/33842508 http://dx.doi.org/10.3389/fmed.2021.644871 Text en Copyright © 2021 Imatoh and Saito. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Imatoh, Takuya
Saito, Yoshiro
Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies
title Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies
title_full Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies
title_fullStr Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies
title_full_unstemmed Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies
title_short Associations Between Stevens–Johnson Syndrome and Infection: Overview of Pharmacoepidemiological Studies
title_sort associations between stevens–johnson syndrome and infection: overview of pharmacoepidemiological studies
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032874/
https://www.ncbi.nlm.nih.gov/pubmed/33842508
http://dx.doi.org/10.3389/fmed.2021.644871
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