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Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf
Sepsis is a frequent life-threatening condition in young calves, requiring rapid broad spectrum and bactericidal therapy to maximize survival chances. Few studies have identified and characterized bacteria involved in sepsis in calves. This report demonstrates the involvement of a multidrug resistan...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032891/ https://www.ncbi.nlm.nih.gov/pubmed/33842574 http://dx.doi.org/10.3389/fvets.2021.631716 |
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author | Pas, Mathilde L. Vanneste, Kevin Bokma, Jade Van Driessche, Laura De Keersmaecker, Sigrid C. J. Roosens, Nancy H. Haesebrouck, Freddy Boyen, Filip Pardon, Bart |
author_facet | Pas, Mathilde L. Vanneste, Kevin Bokma, Jade Van Driessche, Laura De Keersmaecker, Sigrid C. J. Roosens, Nancy H. Haesebrouck, Freddy Boyen, Filip Pardon, Bart |
author_sort | Pas, Mathilde L. |
collection | PubMed |
description | Sepsis is a frequent life-threatening condition in young calves, requiring rapid broad spectrum and bactericidal therapy to maximize survival chances. Few studies have identified and characterized bacteria involved in sepsis in calves. This report demonstrates the involvement of a multidrug resistant Raoultella ornithinolytica, an emerging pathogen in human medicine, in a calf with suspected sepsis. R. ornithinolytica was identified by MALDI-TOF MS from blood cultures of a critically ill calf. Susceptibility testing showed phenotypic resistance against ampicillin, gentamicin, potentiated sulphonamides, streptomycin, tetracyclines and intermediate susceptibility for enrofloxacin. Whole genome sequencing confirmed identification as R. ornithinolytica and the multidrug resistant character of the isolate. Antimicrobial resistance genes acting against aminoglycosides, beta-lactam antibiotics, fosfomycin, quinolones, sulphonamides, trimethoprim and tetracyclines were found. The calf recovered after empirical parenteral therapy with enrofloxacin and sodium penicillin for seven days. Ancillary therapy consisted of fluid therapy, ketoprofen and doxapram hydrochloride. To the authors' knowledge, this is the first report characterizing a multidrug resistant R. ornithinolytica isolate from blood culture in cattle. It is currently unknown whether animals and farms may act as reservoirs for multidrug resistant R. ornithinolytica strains. |
format | Online Article Text |
id | pubmed-8032891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80328912021-04-10 Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf Pas, Mathilde L. Vanneste, Kevin Bokma, Jade Van Driessche, Laura De Keersmaecker, Sigrid C. J. Roosens, Nancy H. Haesebrouck, Freddy Boyen, Filip Pardon, Bart Front Vet Sci Veterinary Science Sepsis is a frequent life-threatening condition in young calves, requiring rapid broad spectrum and bactericidal therapy to maximize survival chances. Few studies have identified and characterized bacteria involved in sepsis in calves. This report demonstrates the involvement of a multidrug resistant Raoultella ornithinolytica, an emerging pathogen in human medicine, in a calf with suspected sepsis. R. ornithinolytica was identified by MALDI-TOF MS from blood cultures of a critically ill calf. Susceptibility testing showed phenotypic resistance against ampicillin, gentamicin, potentiated sulphonamides, streptomycin, tetracyclines and intermediate susceptibility for enrofloxacin. Whole genome sequencing confirmed identification as R. ornithinolytica and the multidrug resistant character of the isolate. Antimicrobial resistance genes acting against aminoglycosides, beta-lactam antibiotics, fosfomycin, quinolones, sulphonamides, trimethoprim and tetracyclines were found. The calf recovered after empirical parenteral therapy with enrofloxacin and sodium penicillin for seven days. Ancillary therapy consisted of fluid therapy, ketoprofen and doxapram hydrochloride. To the authors' knowledge, this is the first report characterizing a multidrug resistant R. ornithinolytica isolate from blood culture in cattle. It is currently unknown whether animals and farms may act as reservoirs for multidrug resistant R. ornithinolytica strains. Frontiers Media S.A. 2021-03-26 /pmc/articles/PMC8032891/ /pubmed/33842574 http://dx.doi.org/10.3389/fvets.2021.631716 Text en Copyright © 2021 Pas, Vanneste, Bokma, Van Driessche, De Keersmaecker, Roosens, Haesebrouck, Boyen and Pardon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Veterinary Science Pas, Mathilde L. Vanneste, Kevin Bokma, Jade Van Driessche, Laura De Keersmaecker, Sigrid C. J. Roosens, Nancy H. Haesebrouck, Freddy Boyen, Filip Pardon, Bart Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf |
title | Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf |
title_full | Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf |
title_fullStr | Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf |
title_full_unstemmed | Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf |
title_short | Case Report: Multidrug Resistant Raoultella ornithinolytica in a Septicemic Calf |
title_sort | case report: multidrug resistant raoultella ornithinolytica in a septicemic calf |
topic | Veterinary Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032891/ https://www.ncbi.nlm.nih.gov/pubmed/33842574 http://dx.doi.org/10.3389/fvets.2021.631716 |
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