Cargando…

Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiates infection by attachment of the surface-exposed spike glycoprotein to the host cell receptors. The spike glycoprotein (S) is a promising target for inducing immune responses and providing protection; thus the ongoing efforts for t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vishwakarma, Preeti, Yadav, Naveen, Rizvi, Zaigham Abbas, Khan, Naseem Ahmed, Chiranjivi, Adarsh Kumar, Mani, Shailendra, Bansal, Manish, Dwivedi, Prabhanjan, Shrivastava, Tripti, Kumar, Rajesh, Awasthi, Amit, Ahmed, Shubbir, Samal, Sweety
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032902/ https://www.ncbi.nlm.nih.gov/pubmed/33841395 http://dx.doi.org/10.3389/fimmu.2021.613045

Ejemplares similares

Identification of an anti–SARS–CoV-2 receptor-binding domain–directed human monoclonal antibody from a naïve semisynthetic library
por: Parray, Hilal Ahmad, et al.
Publicado: (2020)

Correction: Tetramerizing tGCN4 domain facilitates production of Influenza A H1N1 M2e higher order soluble oligomers that show enhanced immunogenicity in vivo
por: Samal, Sweety, et al.
Publicado: (2021)

Comparative immunogenicity analysis of intradermal versus intramuscular administration of SARS-CoV-2 RBD epitope peptide-based immunogen In vivo
por: Yadav, Naveen, et al.
Publicado: (2021)

Designing and characterization of a SARS-CoV-2 immunogen with receptor binding motif grafted on a protein scaffold: An epitope-focused vaccine approach
por: Khatri, Ritika, et al.
Publicado: (2022)

Antibody-based therapeutic interventions: possible strategy to counter chikungunya viral infection
por: Kumar, Rajesh, et al.
Publicado: (2020)

Non-neutralizing SARS CoV-2 directed polyclonal antibodies demonstrate cross-reactivity with the HA glycans of influenza virus
por: Murugavelu, Praveenkumar, et al.
Publicado: (2021)

Hybridoma technology a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives
por: Parray, Hilal Ahmed, et al.
Publicado: (2020)

Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 Variants
por: Khatri, Ritika, et al.
Publicado: (2022)

Comparative Immunomodulatory Evaluation of the Receptor Binding Domain of the SARS-CoV-2 Spike Protein; a Potential Vaccine Candidate Which Imparts Potent Humoral and Th1 Type Immune Response in a Mouse Model
por: Shrivastava, Tripti, et al.
Publicado: (2021)

The SARS CoV-2 spike directed non-neutralizing polyclonal antibodies cross-react with Human immunodeficiency virus (HIV-1) gp41
por: Perween, Reshma, et al.
Publicado: (2021)

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo
por: Raj, Sneha, et al.
Publicado: (2023)

Intrinsic D614G and P681R/H mutations in SARS-CoV-2 VoCs Alpha, Delta, Omicron and viruses with D614G plus key signature mutations in spike protein alters fusogenicity and infectivity
por: Khatri, Ritika, et al.
Publicado: (2022)

Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2022)

Efficiently cleaved HIV-1 envelopes: can they be important for vaccine immunogen development?
por: Das, Supratik, et al.
Publicado: (2020)

A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern
por: Parray, Hilal Ahmad, et al.
Publicado: (2022)

Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections
por: Parray, Hilal Ahmad, et al.
Publicado: (2021)

Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail
por: Samal, Sweety, et al.
Publicado: (2018)

Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein
por: Ahmed, Shubbir, et al.
Publicado: (2017)

Membrane bound modified form of clade B Env, JRCSF is suitable for immunogen design as it is efficiently cleaved and displays all the broadly neutralizing epitopes including V2 and C2 domain-dependent conformational epitopes
por: Das, Supratik, et al.
Publicado: (2016)

Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: a test-negative, case-control study and a mechanistic study of post-vaccination immune responses
por: Thiruvengadam, Ramachandran, et al.
Publicado: (2022)

Method to identify efficiently cleaved, membrane-bound, functional HIV-1 (Human Immunodeficiency Virus-1) envelopes
por: Samal, Sweety, et al.
Publicado: (2019)

Characterization of a broadly cross reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS-CoV-2
por: Garg, Sonal, et al.
Publicado: (2022)

An Efficiently Cleaved HIV-1 Clade C Env Selectively Binds to Neutralizing Antibodies
por: Boliar, Saikat, et al.
Publicado: (2015)

Evaluation of Ayush-64 (a Polyherbal Formulation) and Its Ingredients in the Syrian Hamster Model for SARS-CoV-2 Infection Reveals the Preventative Potential of Alstonia scholaris
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2023)

Clinical and experimental evidence suggest omicron variant of SARS-CoV-2 is inherently less pathogenic than delta variant independent of previous immunity
por: Thiruvengadam, Ramachandran, et al.
Publicado: (2023)

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2022)

Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2023)

Proinflammatory Innate Cytokines and Distinct Metabolomic Signatures Shape the T Cell Response in Active COVID-19
por: Binayke, Akshay, et al.
Publicado: (2022)

Respiratory Syncytial Virus-Induced Oxidative Stress Leads to an Increase in Labile Zinc Pools in Lung Epithelial Cells
por: Khan, Naseem Ahmed, et al.
Publicado: (2020)

BLIMP-1 Mediated Downregulation of TAK1 and p53 Molecules Is Crucial in the Pathogenesis of Kala-Azar
por: Saha, Gundappa, et al.
Publicado: (2020)

Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2023)

High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2021)

Amaranthus Biochar-Based Microbial Cell Composites for Alleviation of Drought and Cadmium Stress: A Novel Bioremediation Approach
por: Tripti,, et al.
Publicado: (2023)

Metabolic Checkpoints in Differentiation of Helper T Cells in Tissue Inflammation
por: Roy, Suyasha, et al.
Publicado: (2019)

Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2021)

Design of commercially comparable nanotherapeutic agent against human disease-causing parasite, Leishmania
por: Baranwal, Anupriya, et al.
Publicado: (2018)

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant
por: Hingankar, Nitin, et al.
Publicado: (2022)

In silico Identification of IgE-Binding Epitopes of Osmotin Protein
por: Sharma, Prerna, et al.
Publicado: (2013)

Efficient, highly diastereoselective MS 4 Å-promoted one-pot, three-component synthesis of 2,6-disubstituted-4-tosyloxytetrahydropyrans via Prins cyclization
por: Ahmed, Naseem, et al.
Publicado: (2012)

G4-binding drugs, chlorpromazine and prochlorperazine, repurposed against COVID-19 infection in hamsters
por: Roy, Shuvra Shekhar, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_md5ag7i3mfb0etdti91jh1c4vi