The Role of CD276 in Cancers

OBJECTIVE: Aberrant expression of the immune checkpoint molecule, CD276, also known as B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe the role of CD276 in malignancies and its potential therapeutic effect. DATA SOURCES: Database including PubMed, EMbase,...

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Autores principales: Liu, Shengzhuo, Liang, Jiayu, Liu, Zhihong, Zhang, Chi, Wang, Yang, Watson, Alice Helen, Zhou, Chuan, Zhang, Fan, Wu, Kan, Zhang, Fuxun, Lu, Yiping, Wang, Xianding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032984/
https://www.ncbi.nlm.nih.gov/pubmed/33842369
http://dx.doi.org/10.3389/fonc.2021.654684
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author Liu, Shengzhuo
Liang, Jiayu
Liu, Zhihong
Zhang, Chi
Wang, Yang
Watson, Alice Helen
Zhou, Chuan
Zhang, Fan
Wu, Kan
Zhang, Fuxun
Lu, Yiping
Wang, Xianding
author_facet Liu, Shengzhuo
Liang, Jiayu
Liu, Zhihong
Zhang, Chi
Wang, Yang
Watson, Alice Helen
Zhou, Chuan
Zhang, Fan
Wu, Kan
Zhang, Fuxun
Lu, Yiping
Wang, Xianding
author_sort Liu, Shengzhuo
collection PubMed
description OBJECTIVE: Aberrant expression of the immune checkpoint molecule, CD276, also known as B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe the role of CD276 in malignancies and its potential therapeutic effect. DATA SOURCES: Database including PubMed, EMbase, Cochrane Library, CNKI, and Clinical Trails.gov were searched for eligible studies and reviews. Study selection: Original studies and review articles on the topic of CD276 in tumors were retrieved. RESULTS: CD276 is an immune checkpoint molecule in the epithelial mesenchymal transition (EMT) pathway. In this review, we evaluated the available evidence on the expression and regulation of CD276. We also assessed the role of CD276 within the immune micro-environment, effect on tumor progression, and the potential therapeutic effect of CD276 targeted therapy for malignancies. CONCLUSION: CD276 plays an essential role in cell proliferation, invasion, and migration in malignancies. Results from most recent studies indicate CD276 could be a promising therapeutic target for malignant tumors.
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spelling pubmed-80329842021-04-10 The Role of CD276 in Cancers Liu, Shengzhuo Liang, Jiayu Liu, Zhihong Zhang, Chi Wang, Yang Watson, Alice Helen Zhou, Chuan Zhang, Fan Wu, Kan Zhang, Fuxun Lu, Yiping Wang, Xianding Front Oncol Oncology OBJECTIVE: Aberrant expression of the immune checkpoint molecule, CD276, also known as B7-H3, is associated with tumorigenesis. In this review, we aim to comprehensively describe the role of CD276 in malignancies and its potential therapeutic effect. DATA SOURCES: Database including PubMed, EMbase, Cochrane Library, CNKI, and Clinical Trails.gov were searched for eligible studies and reviews. Study selection: Original studies and review articles on the topic of CD276 in tumors were retrieved. RESULTS: CD276 is an immune checkpoint molecule in the epithelial mesenchymal transition (EMT) pathway. In this review, we evaluated the available evidence on the expression and regulation of CD276. We also assessed the role of CD276 within the immune micro-environment, effect on tumor progression, and the potential therapeutic effect of CD276 targeted therapy for malignancies. CONCLUSION: CD276 plays an essential role in cell proliferation, invasion, and migration in malignancies. Results from most recent studies indicate CD276 could be a promising therapeutic target for malignant tumors. Frontiers Media S.A. 2021-03-26 /pmc/articles/PMC8032984/ /pubmed/33842369 http://dx.doi.org/10.3389/fonc.2021.654684 Text en Copyright © 2021 Liu, Liang, Liu, Zhang, Wang, Watson, Zhou, Zhang, Wu, Zhang, Lu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Shengzhuo
Liang, Jiayu
Liu, Zhihong
Zhang, Chi
Wang, Yang
Watson, Alice Helen
Zhou, Chuan
Zhang, Fan
Wu, Kan
Zhang, Fuxun
Lu, Yiping
Wang, Xianding
The Role of CD276 in Cancers
title The Role of CD276 in Cancers
title_full The Role of CD276 in Cancers
title_fullStr The Role of CD276 in Cancers
title_full_unstemmed The Role of CD276 in Cancers
title_short The Role of CD276 in Cancers
title_sort role of cd276 in cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8032984/
https://www.ncbi.nlm.nih.gov/pubmed/33842369
http://dx.doi.org/10.3389/fonc.2021.654684
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