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The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin
There are three types of proteins in coronaviruses: nonstructural, structural, and accessory proteins. Coronavirus proteins are essential for viral replication and for the binding and invasion of hosts and the regulation of host cell metabolism and immunity. This study investigated the amino acid se...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Singapore
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033097/ https://www.ncbi.nlm.nih.gov/pubmed/33850392 http://dx.doi.org/10.1007/s42485-021-00060-3 |
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author | Mohammed, Mohammed Elimam Ahamed |
author_facet | Mohammed, Mohammed Elimam Ahamed |
author_sort | Mohammed, Mohammed Elimam Ahamed |
collection | PubMed |
description | There are three types of proteins in coronaviruses: nonstructural, structural, and accessory proteins. Coronavirus proteins are essential for viral replication and for the binding and invasion of hosts and the regulation of host cell metabolism and immunity. This study investigated the amino acid sequence similarity and identity percentages of 10 proteins in SARS-CoV-2, SARS-CoV and the Rhinolophus affinis bat coronavirus (BatCoV RaTG13). The investigated proteins were the 1ab polyprotein, spike protein, orf3a, the envelope protein, the membrane protein, orf6, orf7a, orf7b, orf8, and the nucleocapsid protein. The online sequence alignment service of The European Molecular Biology Open Software Suite (EMBOSS) was used to determine the percentages of protein similarity and identity in the three viruses. The results showed that the similarity and identity percentages of the SARS-CoV-2 and BatCoV RaTG13 proteins were both greater than 95%, while the identity and similarity percentages of SARS-CoV-2 and SARS-CoV were both greater than 38%. The proteins of SARS-CoV-2 and BatCoV RaTG13 have high identity and similarity compared to those of SARS-CoV-2 and SARS-CoV. GRAPHIC ABSTRACT: The proteins of the SARS-CoV-2 are most identical and similar to those of BatCoV RaTG13 than to the proteins of SARS-CoV [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s42485-021-00060-3. |
format | Online Article Text |
id | pubmed-8033097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-80330972021-04-09 The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin Mohammed, Mohammed Elimam Ahamed J Proteins Proteom Original Article There are three types of proteins in coronaviruses: nonstructural, structural, and accessory proteins. Coronavirus proteins are essential for viral replication and for the binding and invasion of hosts and the regulation of host cell metabolism and immunity. This study investigated the amino acid sequence similarity and identity percentages of 10 proteins in SARS-CoV-2, SARS-CoV and the Rhinolophus affinis bat coronavirus (BatCoV RaTG13). The investigated proteins were the 1ab polyprotein, spike protein, orf3a, the envelope protein, the membrane protein, orf6, orf7a, orf7b, orf8, and the nucleocapsid protein. The online sequence alignment service of The European Molecular Biology Open Software Suite (EMBOSS) was used to determine the percentages of protein similarity and identity in the three viruses. The results showed that the similarity and identity percentages of the SARS-CoV-2 and BatCoV RaTG13 proteins were both greater than 95%, while the identity and similarity percentages of SARS-CoV-2 and SARS-CoV were both greater than 38%. The proteins of SARS-CoV-2 and BatCoV RaTG13 have high identity and similarity compared to those of SARS-CoV-2 and SARS-CoV. GRAPHIC ABSTRACT: The proteins of the SARS-CoV-2 are most identical and similar to those of BatCoV RaTG13 than to the proteins of SARS-CoV [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s42485-021-00060-3. Springer Singapore 2021-04-09 2021 /pmc/articles/PMC8033097/ /pubmed/33850392 http://dx.doi.org/10.1007/s42485-021-00060-3 Text en © The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Article Mohammed, Mohammed Elimam Ahamed The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin |
title | The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin |
title_full | The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin |
title_fullStr | The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin |
title_full_unstemmed | The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin |
title_short | The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin |
title_sort | percentages of sars-cov-2 protein similarity and identity with sars-cov and batcov ratg13 proteins can be used as indicators of virus origin |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033097/ https://www.ncbi.nlm.nih.gov/pubmed/33850392 http://dx.doi.org/10.1007/s42485-021-00060-3 |
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