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Childhood Cancer Survival in Brunei Darussalam

BACKGROUND: This study aims to determine the survival rates for children and adolescents aged 0-19 years diagnosed with childhood cancer and to evaluate the associated factors for childhood cancer survival in Brunei Darussalam. METHODS: The analysis was based on de-identified data of 263 childhood c...

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Autores principales: Leong, Elvynna, Ong, Sok King, Jali, Fadzilah, Ramlee, Noraslinah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033123/
https://www.ncbi.nlm.nih.gov/pubmed/33247683
http://dx.doi.org/10.31557/APJCP.2020.21.11.3259
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author Leong, Elvynna
Ong, Sok King
Jali, Fadzilah
Ramlee, Noraslinah
author_facet Leong, Elvynna
Ong, Sok King
Jali, Fadzilah
Ramlee, Noraslinah
author_sort Leong, Elvynna
collection PubMed
description BACKGROUND: This study aims to determine the survival rates for children and adolescents aged 0-19 years diagnosed with childhood cancer and to evaluate the associated factors for childhood cancer survival in Brunei Darussalam. METHODS: The analysis was based on de-identified data of 263 childhood cancer for the period 2002 to 2017 retrieved from a population-based cancer registry. Overall survival was estimated using the Kaplan-Meier method. Univariate analysis, using the log-rank test, was used to examine the differences in survival between groups. Multivariate analysis, using the Cox Proportional Hazard (PH) regression model, was used to estimate the hazard ratios (HRs) and select the significant associated factors for childhood cancer patients’ survival. RESULTS: The overall 1-, 5- and 10-year survival rates for all childhood cancers combined were 79.4%, 70.0% and 68.8% respectively. The most common types of cancer were leukemias, malignant epithelial neoplasms, lymphomas and tumours of the central nervous system (CNS). The 5-year survival estimates were highest for malignant epithelial neoplasms (84.2%) while the lowest was tumours of the CNS (44.1%). Log rank tests showed significant differences in childhood cancer patients’ survival between tumour types and period of diagnosis. In the Cox PH analysis, the presence of lymphomas, gonodal and germ cell neoplasms, and malignant epithelial neoplasms compared to leukemia; children aged 1-4 and 5-9 years compared to adolescents aged 15-19 years; and periods of diagnosis in 2002-2006 and 2007-2011 compared to 2012-2017 were significantly associated with lower hazard of death in this study. CONCLUSION: This study provides a baseline measurement of childhood cancer survival for monitoring and evaluation of cancer control programmes, to allow planning of cancer control program strategies such as surveillance, screening, and treatment to improve childhood survival rates in Brunei Darussalam.
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spelling pubmed-80331232021-04-09 Childhood Cancer Survival in Brunei Darussalam Leong, Elvynna Ong, Sok King Jali, Fadzilah Ramlee, Noraslinah Asian Pac J Cancer Prev Research Article BACKGROUND: This study aims to determine the survival rates for children and adolescents aged 0-19 years diagnosed with childhood cancer and to evaluate the associated factors for childhood cancer survival in Brunei Darussalam. METHODS: The analysis was based on de-identified data of 263 childhood cancer for the period 2002 to 2017 retrieved from a population-based cancer registry. Overall survival was estimated using the Kaplan-Meier method. Univariate analysis, using the log-rank test, was used to examine the differences in survival between groups. Multivariate analysis, using the Cox Proportional Hazard (PH) regression model, was used to estimate the hazard ratios (HRs) and select the significant associated factors for childhood cancer patients’ survival. RESULTS: The overall 1-, 5- and 10-year survival rates for all childhood cancers combined were 79.4%, 70.0% and 68.8% respectively. The most common types of cancer were leukemias, malignant epithelial neoplasms, lymphomas and tumours of the central nervous system (CNS). The 5-year survival estimates were highest for malignant epithelial neoplasms (84.2%) while the lowest was tumours of the CNS (44.1%). Log rank tests showed significant differences in childhood cancer patients’ survival between tumour types and period of diagnosis. In the Cox PH analysis, the presence of lymphomas, gonodal and germ cell neoplasms, and malignant epithelial neoplasms compared to leukemia; children aged 1-4 and 5-9 years compared to adolescents aged 15-19 years; and periods of diagnosis in 2002-2006 and 2007-2011 compared to 2012-2017 were significantly associated with lower hazard of death in this study. CONCLUSION: This study provides a baseline measurement of childhood cancer survival for monitoring and evaluation of cancer control programmes, to allow planning of cancer control program strategies such as surveillance, screening, and treatment to improve childhood survival rates in Brunei Darussalam. West Asia Organization for Cancer Prevention 2020-11 /pmc/articles/PMC8033123/ /pubmed/33247683 http://dx.doi.org/10.31557/APJCP.2020.21.11.3259 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Leong, Elvynna
Ong, Sok King
Jali, Fadzilah
Ramlee, Noraslinah
Childhood Cancer Survival in Brunei Darussalam
title Childhood Cancer Survival in Brunei Darussalam
title_full Childhood Cancer Survival in Brunei Darussalam
title_fullStr Childhood Cancer Survival in Brunei Darussalam
title_full_unstemmed Childhood Cancer Survival in Brunei Darussalam
title_short Childhood Cancer Survival in Brunei Darussalam
title_sort childhood cancer survival in brunei darussalam
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033123/
https://www.ncbi.nlm.nih.gov/pubmed/33247683
http://dx.doi.org/10.31557/APJCP.2020.21.11.3259
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