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PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway

BACKGROUND: Triple-negative breast cancer (TNBC) is a malignant subtype of breast cancer, the main treatments for which are chemotherapy and surgery. PIK3CA is an oncogene that encodes the p110α subunit of class IA PI3K to regulate cell proliferation and apoptosis. Some reports have observed neoadju...

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Detalles Bibliográficos
Autores principales:	Hu, Huayu, Zhu, Junyong, Zhong, Yuting, Geng, Rui, Ji, Yashuang, Guan, Qingyu, Hong, Chenyan, Wei, Yufan, Min, Ningning, Qi, Aiying, Zhang, Yanjun, Li, Xiru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033310/ https://www.ncbi.nlm.nih.gov/pubmed/33842631 http://dx.doi.org/10.21037/atm-21-698

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