Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism

BACKGROUND: Ventricular-like human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) exhibit the electrophysiological characteristics of spontaneous beating. Previous studies demonstrated that dexmedetomidine (DMED), a highly selective and widely used α(2)-adrenoceptor agonist for sed...

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Detalles Bibliográficos
Autores principales: Yang, Li, Gong, Yiqi, Tan, Yao, Wu, Lei, Witman, Nevin, Zheng, Jijian, Zhang, Jun, Fu, Wei, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033317/
https://www.ncbi.nlm.nih.gov/pubmed/33842620
http://dx.doi.org/10.21037/atm-20-5898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033317/
https://www.ncbi.nlm.nih.gov/pubmed/33842620
http://dx.doi.org/10.21037/atm-20-5898

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