Cargando…
The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review
Neoadjuvant treatment followed by esophagectomy has been the standard strategy for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Pathological response after neoadjuvant treatment is of vital importance in the determination of long-term survival. Due to the involvement of mic...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033340/ https://www.ncbi.nlm.nih.gov/pubmed/33842641 http://dx.doi.org/10.21037/atm-20-3000 |
_version_ | 1783676392927395840 |
---|---|
author | Lin, Dong Chen, Xiaosang Tan, Lijie |
author_facet | Lin, Dong Chen, Xiaosang Tan, Lijie |
author_sort | Lin, Dong |
collection | PubMed |
description | Neoadjuvant treatment followed by esophagectomy has been the standard strategy for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Pathological response after neoadjuvant treatment is of vital importance in the determination of long-term survival. Due to the involvement of microRNAs (miRNAs) in ESCC, some studies have proposed miRNA models to predict the pathological response. We aimed to summarize current studies on the predictive value of the miRNA models. We searched the relevant studies on PubMed, Web of Science and Cochrane Library up to February 14, 2020, using the following search term: (esophageal OR esophagus OR oesophageal OR oesophagus) AND (miR OR miRNA OR microRNA) AND (neoadjuvant OR preoperative OR induction). The initial search retrieved 206 studies. We briefly summarized the involvement of miRNAs in the origin, development and chemo- and radioresistance in ESCC. Then, 9 studies were enrolled in the systematic review. A great heterogeneity was observed across these studies. Of the 6 studies with diagnostic tests, the area under curve varied a lot. Although much evidence demonstrated the correlation between miRNAs and pathological response after in ESCC, the current studies has not established any promising models. A well-designed prospective study is essential to investigate the potential predictive models for pathological response after neoadjuvant treatment in ESCC. |
format | Online Article Text |
id | pubmed-8033340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-80333402021-04-09 The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review Lin, Dong Chen, Xiaosang Tan, Lijie Ann Transl Med Review Article Neoadjuvant treatment followed by esophagectomy has been the standard strategy for resectable locally advanced esophageal squamous cell carcinoma (ESCC). Pathological response after neoadjuvant treatment is of vital importance in the determination of long-term survival. Due to the involvement of microRNAs (miRNAs) in ESCC, some studies have proposed miRNA models to predict the pathological response. We aimed to summarize current studies on the predictive value of the miRNA models. We searched the relevant studies on PubMed, Web of Science and Cochrane Library up to February 14, 2020, using the following search term: (esophageal OR esophagus OR oesophageal OR oesophagus) AND (miR OR miRNA OR microRNA) AND (neoadjuvant OR preoperative OR induction). The initial search retrieved 206 studies. We briefly summarized the involvement of miRNAs in the origin, development and chemo- and radioresistance in ESCC. Then, 9 studies were enrolled in the systematic review. A great heterogeneity was observed across these studies. Of the 6 studies with diagnostic tests, the area under curve varied a lot. Although much evidence demonstrated the correlation between miRNAs and pathological response after in ESCC, the current studies has not established any promising models. A well-designed prospective study is essential to investigate the potential predictive models for pathological response after neoadjuvant treatment in ESCC. AME Publishing Company 2021-03 /pmc/articles/PMC8033340/ /pubmed/33842641 http://dx.doi.org/10.21037/atm-20-3000 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article Lin, Dong Chen, Xiaosang Tan, Lijie The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review |
title | The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review |
title_full | The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review |
title_fullStr | The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review |
title_full_unstemmed | The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review |
title_short | The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review |
title_sort | predictive value of micrornas for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033340/ https://www.ncbi.nlm.nih.gov/pubmed/33842641 http://dx.doi.org/10.21037/atm-20-3000 |
work_keys_str_mv | AT lindong thepredictivevalueofmicrornasforpathologicalresponseafterneoadjuvanttreatmentinesophagealsquamouscellcarcinomaasystematicreview AT chenxiaosang thepredictivevalueofmicrornasforpathologicalresponseafterneoadjuvanttreatmentinesophagealsquamouscellcarcinomaasystematicreview AT tanlijie thepredictivevalueofmicrornasforpathologicalresponseafterneoadjuvanttreatmentinesophagealsquamouscellcarcinomaasystematicreview AT lindong predictivevalueofmicrornasforpathologicalresponseafterneoadjuvanttreatmentinesophagealsquamouscellcarcinomaasystematicreview AT chenxiaosang predictivevalueofmicrornasforpathologicalresponseafterneoadjuvanttreatmentinesophagealsquamouscellcarcinomaasystematicreview AT tanlijie predictivevalueofmicrornasforpathologicalresponseafterneoadjuvanttreatmentinesophagealsquamouscellcarcinomaasystematicreview |