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Environmental triggers of dermatomyositis: a narrative review
Dermatomyositis (DM) is an autoimmune disease that affects the skin, lungs, and muscle. Although the pathogenesis of DM is not completely understood, several environmental triggers have been linked to DM onset or flare. This article specifically examines the effects of herbal supplements, drugs, inf...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033368/ https://www.ncbi.nlm.nih.gov/pubmed/33842655 http://dx.doi.org/10.21037/atm-20-3719 |
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author | Bax, Christina E. Maddukuri, Spandana Ravishankar, Adarsh Pappas-Taffer, Lisa Werth, Victoria P. |
author_facet | Bax, Christina E. Maddukuri, Spandana Ravishankar, Adarsh Pappas-Taffer, Lisa Werth, Victoria P. |
author_sort | Bax, Christina E. |
collection | PubMed |
description | Dermatomyositis (DM) is an autoimmune disease that affects the skin, lungs, and muscle. Although the pathogenesis of DM is not completely understood, several environmental triggers have been linked to DM onset or flare. This article specifically examines the effects of herbal supplements, drugs, infections, ultraviolet (UV) radiation, and environmental pollutants on the onset or exacerbation of DM. Herbal supplements such as Spirulina platensis, Aphanizomenon flos-aquae, Chlorella, Echinacea, and Alfalfa have been implicated and are frequently used in health foods. Medications such as hydroxyurea, TNF-α inhibitors, immune checkpoint inhibitors (ICI), and penicillamine, as well as certain viral infections, such as parvovirus B19, coxsackie virus, polyomavirus, Epstein-Barr virus (EBV), hepatitis, influenza, and human immunodeficiency viruses (HIV) have been associated with DM onset. Bacterial infections and vaccinations have also been linked to the development of DM. Additional environmental factors, including UV radiation and air pollutants, such as silica, biological/mineral dust, and particulate air matter from vehicle and industrial emissions, may also play a role in DM pathogenesis. Overall, there is general agreement that an autoimmune attack of the skin, muscle, and lungs in DM can be triggered by various environmental factors and warrants further investigation. |
format | Online Article Text |
id | pubmed-8033368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-80333682021-04-09 Environmental triggers of dermatomyositis: a narrative review Bax, Christina E. Maddukuri, Spandana Ravishankar, Adarsh Pappas-Taffer, Lisa Werth, Victoria P. Ann Transl Med Review Article on Rheumatologic Skin Disease Dermatomyositis (DM) is an autoimmune disease that affects the skin, lungs, and muscle. Although the pathogenesis of DM is not completely understood, several environmental triggers have been linked to DM onset or flare. This article specifically examines the effects of herbal supplements, drugs, infections, ultraviolet (UV) radiation, and environmental pollutants on the onset or exacerbation of DM. Herbal supplements such as Spirulina platensis, Aphanizomenon flos-aquae, Chlorella, Echinacea, and Alfalfa have been implicated and are frequently used in health foods. Medications such as hydroxyurea, TNF-α inhibitors, immune checkpoint inhibitors (ICI), and penicillamine, as well as certain viral infections, such as parvovirus B19, coxsackie virus, polyomavirus, Epstein-Barr virus (EBV), hepatitis, influenza, and human immunodeficiency viruses (HIV) have been associated with DM onset. Bacterial infections and vaccinations have also been linked to the development of DM. Additional environmental factors, including UV radiation and air pollutants, such as silica, biological/mineral dust, and particulate air matter from vehicle and industrial emissions, may also play a role in DM pathogenesis. Overall, there is general agreement that an autoimmune attack of the skin, muscle, and lungs in DM can be triggered by various environmental factors and warrants further investigation. AME Publishing Company 2021-03 /pmc/articles/PMC8033368/ /pubmed/33842655 http://dx.doi.org/10.21037/atm-20-3719 Text en 2021 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Review Article on Rheumatologic Skin Disease Bax, Christina E. Maddukuri, Spandana Ravishankar, Adarsh Pappas-Taffer, Lisa Werth, Victoria P. Environmental triggers of dermatomyositis: a narrative review |
title | Environmental triggers of dermatomyositis: a narrative review |
title_full | Environmental triggers of dermatomyositis: a narrative review |
title_fullStr | Environmental triggers of dermatomyositis: a narrative review |
title_full_unstemmed | Environmental triggers of dermatomyositis: a narrative review |
title_short | Environmental triggers of dermatomyositis: a narrative review |
title_sort | environmental triggers of dermatomyositis: a narrative review |
topic | Review Article on Rheumatologic Skin Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033368/ https://www.ncbi.nlm.nih.gov/pubmed/33842655 http://dx.doi.org/10.21037/atm-20-3719 |
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