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Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study

AIMS: The authors sought to examine associations between urinary exosomal miRNAs (exo-miRs), emerging biomarkers of renal health, and cardiorenal outcomes in early childhood. MATERIALS & METHODS: The authors extracted exo-miRs in urine from 88 healthy Mexican children aged 4–6 years. The authors...

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Autores principales: Levin-Schwartz, Yuri, Curtin, Paul, Flores, Daniel, Aushev, Vasily N, Tamayo-Ortiz, Marcela, Svensson, Katherine, Pantic, Ivan, Estrada-Gutierrez, Guadalupe, Pizano-Zárate, María L, Gennings, Chris, Satlin, Lisa M, Baccarelli, Andrea A, Tellez-Rojo, Martha M, Wright, Robert O, Sanders, Alison P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033423/
https://www.ncbi.nlm.nih.gov/pubmed/33635093
http://dx.doi.org/10.2217/epi-2020-0342
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author Levin-Schwartz, Yuri
Curtin, Paul
Flores, Daniel
Aushev, Vasily N
Tamayo-Ortiz, Marcela
Svensson, Katherine
Pantic, Ivan
Estrada-Gutierrez, Guadalupe
Pizano-Zárate, María L
Gennings, Chris
Satlin, Lisa M
Baccarelli, Andrea A
Tellez-Rojo, Martha M
Wright, Robert O
Sanders, Alison P
author_facet Levin-Schwartz, Yuri
Curtin, Paul
Flores, Daniel
Aushev, Vasily N
Tamayo-Ortiz, Marcela
Svensson, Katherine
Pantic, Ivan
Estrada-Gutierrez, Guadalupe
Pizano-Zárate, María L
Gennings, Chris
Satlin, Lisa M
Baccarelli, Andrea A
Tellez-Rojo, Martha M
Wright, Robert O
Sanders, Alison P
author_sort Levin-Schwartz, Yuri
collection PubMed
description AIMS: The authors sought to examine associations between urinary exosomal miRNAs (exo-miRs), emerging biomarkers of renal health, and cardiorenal outcomes in early childhood. MATERIALS & METHODS: The authors extracted exo-miRs in urine from 88 healthy Mexican children aged 4–6 years. The authors measured associations between 193 exo-miRs and cardiorenal outcomes: systolic/diastolic blood pressure, estimated glomerular filtration rate and urinary sodium and potassium levels. The authors adjusted for age, sex, BMI, socioeconomic status, indoor tobacco smoke exposure and urine specific gravity. RESULTS: Multiple exo-miRs were identified meeting a false discovery rate threshold of q < 0.1. Specifically, three exo-miRs had increased expression with urinary sodium, 17 with urinary sodium-to-potassium ratio and one with decreased estimated glomerular filtration rate. CONCLUSIONS: These results highlight urinary exo-miRs as early-life biomarkers of children's cardiorenal health.
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spelling pubmed-80334232021-04-14 Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study Levin-Schwartz, Yuri Curtin, Paul Flores, Daniel Aushev, Vasily N Tamayo-Ortiz, Marcela Svensson, Katherine Pantic, Ivan Estrada-Gutierrez, Guadalupe Pizano-Zárate, María L Gennings, Chris Satlin, Lisa M Baccarelli, Andrea A Tellez-Rojo, Martha M Wright, Robert O Sanders, Alison P Epigenomics Research Article AIMS: The authors sought to examine associations between urinary exosomal miRNAs (exo-miRs), emerging biomarkers of renal health, and cardiorenal outcomes in early childhood. MATERIALS & METHODS: The authors extracted exo-miRs in urine from 88 healthy Mexican children aged 4–6 years. The authors measured associations between 193 exo-miRs and cardiorenal outcomes: systolic/diastolic blood pressure, estimated glomerular filtration rate and urinary sodium and potassium levels. The authors adjusted for age, sex, BMI, socioeconomic status, indoor tobacco smoke exposure and urine specific gravity. RESULTS: Multiple exo-miRs were identified meeting a false discovery rate threshold of q < 0.1. Specifically, three exo-miRs had increased expression with urinary sodium, 17 with urinary sodium-to-potassium ratio and one with decreased estimated glomerular filtration rate. CONCLUSIONS: These results highlight urinary exo-miRs as early-life biomarkers of children's cardiorenal health. Future Medicine Ltd 2021-02-26 2021-03 /pmc/articles/PMC8033423/ /pubmed/33635093 http://dx.doi.org/10.2217/epi-2020-0342 Text en © 2021 Alison Sanders https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Article
Levin-Schwartz, Yuri
Curtin, Paul
Flores, Daniel
Aushev, Vasily N
Tamayo-Ortiz, Marcela
Svensson, Katherine
Pantic, Ivan
Estrada-Gutierrez, Guadalupe
Pizano-Zárate, María L
Gennings, Chris
Satlin, Lisa M
Baccarelli, Andrea A
Tellez-Rojo, Martha M
Wright, Robert O
Sanders, Alison P
Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study
title Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study
title_full Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study
title_fullStr Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study
title_full_unstemmed Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study
title_short Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study
title_sort exosomal mirnas in urine associated with children's cardiorenal parameters: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033423/
https://www.ncbi.nlm.nih.gov/pubmed/33635093
http://dx.doi.org/10.2217/epi-2020-0342
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