Effect of supplemental dexmedetomidine in interventional embolism on cerebral oxygen metabolism in patients with intracranial aneurysms

OBJECTIVE: To investigate the effect of supplemental dexmedetomidine in interventional embolism on cerebral oxygen metabolism in patients with intracranial aneurysms. METHODS: Ninety patients who underwent interventional embolism of intracranial aneurysms were equally divided into Group A and Group B. In Group A, dexmedetomidine was injected intravenously 10 minutes before inducing anesthesia, with a loading dose of 0.6 µg/kg followed by 0.4 µg/kg/hour. Group B received the same amount of normal saline by the same injection method. Heart rate (HR), mean arterial pressure (MAP), arterial–jugular venous oxygen difference [D(a-jv) (O(2))], cerebral oxygen extraction [CE (O(2))], and intraoperative propofol use were recorded before inducing anesthesia (T(0)) and at five time points thereafter. RESULTS: The amount of propofol in Group A was lower vs Group B. At all five time points after T(0), HR, MAP, D(a-jv) (O(2)), and CE (O(2)) in Group A were significantly lower vs Group B, with significant differences for jugular venous oxygen saturation (S(jv)O(2)) and the oxygen content of the internal jugular vein (C(jv)O(2)) between the groups. CONCLUSION: Dexmedetomidine resulted in less intraoperative propofol, lower D(a-jv) (O(2)) and CE (O(2)), and improved cerebral oxygen metabolism.