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Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study

OBJECTIVE: To explore the relationship between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer (CRC) in the Chinese Han population. METHODS: rs2274907 A>T was assessed by PCR–restriction fragment length polymorphism analysis. Plasma omentin-1 expression from 358 patients wi...

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Autores principales: Zhang, Yaqin, Zhao, Xiaotong, Li, Yongxiang, Wang, Youmin, Chen, Mingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033482/
https://www.ncbi.nlm.nih.gov/pubmed/33823642
http://dx.doi.org/10.1177/03000605211006522
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author Zhang, Yaqin
Zhao, Xiaotong
Li, Yongxiang
Wang, Youmin
Chen, Mingwei
author_facet Zhang, Yaqin
Zhao, Xiaotong
Li, Yongxiang
Wang, Youmin
Chen, Mingwei
author_sort Zhang, Yaqin
collection PubMed
description OBJECTIVE: To explore the relationship between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer (CRC) in the Chinese Han population. METHODS: rs2274907 A>T was assessed by PCR–restriction fragment length polymorphism analysis. Plasma omentin-1 expression from 358 patients with CRC and 286 healthy controls was analyzed by enzyme-linked immunosorbent assay. CRC and control groups were divided into subgroups according to the body mass index (BMI) threshold of 25 kg/m(2). RESULTS: No significant differences were observed between CRC and control groups in terms of genotype or allele frequencies of rs2274907 A>T. Compared with individuals with BMI <25 kg/m(2) and the rs2274907 TT genotype, those with AA+AT genotypes and BMI ≥25 kg/m(2) had a 3.027-fold increased risk of CRC. A significant tendency toward a higher stage of colorectal adenocarcinomas and depth of invasion was observed in individuals with the rs2274907 AA genotype compared with other genotypes. CONCLUSIONS: The omentin-1 gene rs2274907 A>T polymorphism does not seem to play a critical role in the development of CRC in the Chinese Han population, but an interaction between the rs2274907 A allele and BMI may increase the CRC risk. The rs2274907 AA genotype is a potential biomarker for CRC stage progression.
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spelling pubmed-80334822021-04-21 Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study Zhang, Yaqin Zhao, Xiaotong Li, Yongxiang Wang, Youmin Chen, Mingwei J Int Med Res Retrospective Clinical Research Report OBJECTIVE: To explore the relationship between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer (CRC) in the Chinese Han population. METHODS: rs2274907 A>T was assessed by PCR–restriction fragment length polymorphism analysis. Plasma omentin-1 expression from 358 patients with CRC and 286 healthy controls was analyzed by enzyme-linked immunosorbent assay. CRC and control groups were divided into subgroups according to the body mass index (BMI) threshold of 25 kg/m(2). RESULTS: No significant differences were observed between CRC and control groups in terms of genotype or allele frequencies of rs2274907 A>T. Compared with individuals with BMI <25 kg/m(2) and the rs2274907 TT genotype, those with AA+AT genotypes and BMI ≥25 kg/m(2) had a 3.027-fold increased risk of CRC. A significant tendency toward a higher stage of colorectal adenocarcinomas and depth of invasion was observed in individuals with the rs2274907 AA genotype compared with other genotypes. CONCLUSIONS: The omentin-1 gene rs2274907 A>T polymorphism does not seem to play a critical role in the development of CRC in the Chinese Han population, but an interaction between the rs2274907 A allele and BMI may increase the CRC risk. The rs2274907 AA genotype is a potential biomarker for CRC stage progression. SAGE Publications 2021-04-06 /pmc/articles/PMC8033482/ /pubmed/33823642 http://dx.doi.org/10.1177/03000605211006522 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Zhang, Yaqin
Zhao, Xiaotong
Li, Yongxiang
Wang, Youmin
Chen, Mingwei
Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study
title Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study
title_full Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study
title_fullStr Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study
title_full_unstemmed Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study
title_short Association between the omentin-1 gene rs2274907 A>T polymorphism and colorectal cancer in the Chinese Han population: a case-control study
title_sort association between the omentin-1 gene rs2274907 a>t polymorphism and colorectal cancer in the chinese han population: a case-control study
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033482/
https://www.ncbi.nlm.nih.gov/pubmed/33823642
http://dx.doi.org/10.1177/03000605211006522
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