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WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer

Wnt signaling maintains diverse adult stem cell compartments and is implicated in chemotherapy resistance in cancer. PORCN inhibitors that block Wnt secretion have proven effective in Wnt‐addicted preclinical cancer models and are in clinical trials. In a survey for potential combination therapies,...

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Detalles Bibliográficos
Autores principales:	Kaur, Amanpreet, Lim, Jun Yi Stanley, Sepramaniam, Sugunavathi, Patnaik, Siddhi, Harmston, Nathan, Lee, May Ann, Petretto, Enrico, Virshup, David M, Madan, Babita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033517/ https://www.ncbi.nlm.nih.gov/pubmed/33660437 http://dx.doi.org/10.15252/emmm.202013349

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