Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi‐agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high‐throughput drug screens, we uncovered distinct metabolic vulnerabilities and thereby identified...

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Detalles Bibliográficos
Autores principales: Hartleben, Goetz, Schorpp, Kenji, Kwon, Yun, Betz, Barbara, Tsokanos, Foivos‐Filippos, Dantes, Zahra, Schäfer, Arlett, Rothenaigner, Ina, Monroy Kuhn, José Manuel, Morigny, Pauline, Mehr, Lisa, Lin, Sean, Seitz, Susanne, Tokarz, Janina, Artati, Anna, Adamsky, Jerzy, Plettenburg, Oliver, Lutter, Dominik, Irmler, Martin, Beckers, Johannes, Reichert, Maximilian, Hadian, Kamyar, Zeigerer, Anja, Herzig, Stephan, Berriel Diaz, Mauricio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033521/
https://www.ncbi.nlm.nih.gov/pubmed/33665961
http://dx.doi.org/10.15252/emmm.202012461

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