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Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes

BACKGROUND: Avidins are biotin-binding proteins commonly found in the vertebrate eggs. In addition to streptavidin from Streptomyces avidinii, a growing number of avidins have been characterized from divergent bacterial species. However, a systematic research concerning their taxonomy and ecological...

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Autores principales: Laitinen, Olli H., Kuusela, Tanja P., Kukkurainen, Sampo, Nurminen, Anssi, Sinkkonen, Aki, Hytönen, Vesa P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033661/
https://www.ncbi.nlm.nih.gov/pubmed/33836663
http://dx.doi.org/10.1186/s12862-021-01784-y
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author Laitinen, Olli H.
Kuusela, Tanja P.
Kukkurainen, Sampo
Nurminen, Anssi
Sinkkonen, Aki
Hytönen, Vesa P.
author_facet Laitinen, Olli H.
Kuusela, Tanja P.
Kukkurainen, Sampo
Nurminen, Anssi
Sinkkonen, Aki
Hytönen, Vesa P.
author_sort Laitinen, Olli H.
collection PubMed
description BACKGROUND: Avidins are biotin-binding proteins commonly found in the vertebrate eggs. In addition to streptavidin from Streptomyces avidinii, a growing number of avidins have been characterized from divergent bacterial species. However, a systematic research concerning their taxonomy and ecological role has never been done. We performed a search for avidin encoding genes among bacteria using available databases and classified potential avidins according to taxonomy and the ecological niches utilized by host bacteria. RESULTS: Numerous avidin-encoding genes were found in the phyla Actinobacteria and Proteobacteria. The diversity of protein sequences was high and several new variants of genes encoding biotin-binding avidins were found. The living strategies of bacteria hosting avidin encoding genes fall mainly into two categories. Human and animal pathogens were overrepresented among the found bacteria carrying avidin genes. The other widespread category were bacteria that either fix nitrogen or live in root nodules/rhizospheres of plants hosting nitrogen-fixing bacteria. CONCLUSIONS: Bacterial avidins are a taxonomically and ecologically diverse group mainly found in Actinobacteria, Proteobacteria and Bacteroidetes, associated often with plant invasiveness. Avidin encoding genes in plasmids hint that avidins may be horizontally transferred. The current survey may be used as a basis in attempts to understand the ecological significance of biotin-binding capacity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12862-021-01784-y.
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spelling pubmed-80336612021-04-09 Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes Laitinen, Olli H. Kuusela, Tanja P. Kukkurainen, Sampo Nurminen, Anssi Sinkkonen, Aki Hytönen, Vesa P. BMC Ecol Evol Research Article BACKGROUND: Avidins are biotin-binding proteins commonly found in the vertebrate eggs. In addition to streptavidin from Streptomyces avidinii, a growing number of avidins have been characterized from divergent bacterial species. However, a systematic research concerning their taxonomy and ecological role has never been done. We performed a search for avidin encoding genes among bacteria using available databases and classified potential avidins according to taxonomy and the ecological niches utilized by host bacteria. RESULTS: Numerous avidin-encoding genes were found in the phyla Actinobacteria and Proteobacteria. The diversity of protein sequences was high and several new variants of genes encoding biotin-binding avidins were found. The living strategies of bacteria hosting avidin encoding genes fall mainly into two categories. Human and animal pathogens were overrepresented among the found bacteria carrying avidin genes. The other widespread category were bacteria that either fix nitrogen or live in root nodules/rhizospheres of plants hosting nitrogen-fixing bacteria. CONCLUSIONS: Bacterial avidins are a taxonomically and ecologically diverse group mainly found in Actinobacteria, Proteobacteria and Bacteroidetes, associated often with plant invasiveness. Avidin encoding genes in plasmids hint that avidins may be horizontally transferred. The current survey may be used as a basis in attempts to understand the ecological significance of biotin-binding capacity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12862-021-01784-y. BioMed Central 2021-04-09 /pmc/articles/PMC8033661/ /pubmed/33836663 http://dx.doi.org/10.1186/s12862-021-01784-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Laitinen, Olli H.
Kuusela, Tanja P.
Kukkurainen, Sampo
Nurminen, Anssi
Sinkkonen, Aki
Hytönen, Vesa P.
Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes
title Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes
title_full Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes
title_fullStr Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes
title_full_unstemmed Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes
title_short Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes
title_sort bacterial avidins are a widely distributed protein family in actinobacteria, proteobacteria and bacteroidetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033661/
https://www.ncbi.nlm.nih.gov/pubmed/33836663
http://dx.doi.org/10.1186/s12862-021-01784-y
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