Cargando…

Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions

Objectives: Improvements in human stem cell-derived cardiomyocyte (hSC-CM) technology have promoted their use for drug testing and disease investigations. Several in silico hSC-CM models have been proposed to augment interpretation of experimental findings through simulations. This work aims to asse...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paci, Michelangelo, Koivumäki, Jussi T., Lu, Hua Rong, Gallacher, David J., Passini, Elisa, Rodriguez, Blanca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033762/ https://www.ncbi.nlm.nih.gov/pubmed/33841140 http://dx.doi.org/10.3389/fphar.2021.604713

Ejemplares similares

Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach
por: Paci, Michelangelo, et al.
Publicado: (2017)

A mathematical model of hiPSC cardiomyocytes electromechanics
por: Forouzandehmehr, Mohamadamin, et al.
Publicado: (2021)

Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights
por: Forouzandehmehr, Mohamadamin, et al.
Publicado: (2022)

All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation
por: Paci, Michelangelo, et al.
Publicado: (2020)

Simulation of the Effects of Extracellular Calcium Changes Leads to a Novel Computational Model of Human Ventricular Action Potential With a Revised Calcium Handling
por: Bartolucci, Chiara, et al.
Publicado: (2020)

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment
por: Zhou, Xin, et al.
Publicado: (2020)

A Novel In Silico Electromechanical Model of Human Ventricular Cardiomyocyte
por: Bartolucci, Chiara, et al.
Publicado: (2022)

Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model
por: Van de Sande, Dieter V., et al.
Publicado: (2019)

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling
por: Koivumäki, Jussi T., et al.
Publicado: (2018)

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity
por: Passini, Elisa, et al.
Publicado: (2017)

Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study
por: Li, Yanju, et al.
Publicado: (2023)

Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes
por: Paci, Michelangelo, et al.
Publicado: (2012)

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
por: Paci, Michelangelo, et al.
Publicado: (2018)

In vitro effect of hydroxychloroquine on pluripotent stem cells and their cardiomyocytes derivatives
por: Kamga Kapchoup, Michelle Vanessa, et al.
Publicado: (2023)

Anticancer potential of mebendazole against chronic myeloid leukemia: in silico and in vitro studies revealed new insights about the mechanism of action
por: Daniel, Julio Paulino, et al.
Publicado: (2022)

In Silico Screening of the Key Cellular Remodeling Targets in Chronic Atrial Fibrillation
por: Koivumäki, Jussi T., et al.
Publicado: (2014)

Evaluation of chronic drug-induced electrophysiological and cytotoxic effects using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
por: Altrocchi, C., et al.
Publicado: (2023)

Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences
por: Campione, Elena, et al.
Publicado: (2021)

Large-Scale Simulation of the Phenotypical Variability Induced by Loss-of-Function Long QT Mutations in Human Induced Pluripotent Stem Cell Cardiomyocytes
por: Paci, Michelangelo, et al.
Publicado: (2018)

Antihypertensive potential of Brassica rapa leaves: An in vitro and in silico approach
por: Abid, Rohma, et al.
Publicado: (2022)

Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction
por: Trovato, Cristian, et al.
Publicado: (2022)

Impact of Sarcoplasmic Reticulum Calcium Release on Calcium Dynamics and Action Potential Morphology in Human Atrial Myocytes: A Computational Study
por: Koivumäki, Jussi T., et al.
Publicado: (2011)

Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro
por: Kadioglu, Onat, et al.
Publicado: (2017)

Antiarthritic potential of the butanol fraction of Sesuvium sesuvioides: An in vitro, in vivo, and in silico evaluation
por: Sajid-ur-Rehman, Muhammad, et al.
Publicado: (2023)

Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias
por: Passini, Elisa, et al.
Publicado: (2019)

The TCM Preparation Feilike Mixture for the Treatment of Pneumonia: Network Analysis, Pharmacological Assessment and Silico Simulation
por: Peng, Juqin, et al.
Publicado: (2022)

Fibroblast Growth Factor 21 Ameliorates Na(V)1.5 and Kir2.1 Channel Dysregulation in Human AC16 Cardiomyocytes
por: Li, Jiamin, et al.
Publicado: (2021)

Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro
por: Gao, Ge, et al.
Publicado: (2022)

Oridonin Targets Multiple Drug-Resistant Tumor Cells as Determined by in Silico and in Vitro Analyses
por: Kadioglu, Onat, et al.
Publicado: (2018)

In Vitro and In Silico Antidiabetic and Antimicrobial Evaluation of Constituents from Kickxia ramosissima (Nanorrhinum ramosissimum)
por: Amin, Adnan, et al.
Publicado: (2017)

In Silico, Molecular Docking and In Vitro Antimicrobial Activity of the Major Rapeseed Seed Storage Proteins
por: Rahman, Mahmudur, et al.
Publicado: (2020)

Narrowing the Gap Between In Vitro and In Vivo Genetic Profiles by Deconvoluting Toxicogenomic Data In Silico
por: Liu, Yuan, et al.
Publicado: (2020)

2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer’s therapy: In vitro, kinetic, in silico, and in vivo potentials
por: Begum, Farida, et al.
Publicado: (2022)

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalities
por: Trovato, Cristian, et al.
Publicado: (2020)

Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges—The Hamburg perspective
por: Ismaili, Djemail, et al.
Publicado: (2023)

Inhibitory activity of Enhydra fluctuans Lour. on calcium oxalate crystallisation through in silico and in vitro studies
por: Chattaraj, Bornika, et al.
Publicado: (2023)

Natural coumarins from Murraya paniculata as mixed-type inhibitors of cholinesterases: In vitro and in silico investigations
por: Khalid, Asaad, et al.
Publicado: (2023)

Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies
por: Alghamdi, Khalid, et al.
Publicado: (2023)

Resveratrol Targets AKT1 to Inhibit Inflammasome Activation in Cardiomyocytes Under Acute Sympathetic Stress
por: Wang, Rui, et al.
Publicado: (2022)

JZTX-V Targets the Voltage Sensor in Kv4.2 to Inhibit I(to) Potassium Channels in Cardiomyocytes
por: Zhang, Yiya, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5j033k16bljdosroibsu6fi25s