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The Links between Cardiovascular Diseases and Alzheimer's Disease

The root cause of non-inherited Alzheimer’s disease (AD) remains unknown despite hundreds of research studies performed to attempt to solve this problem. Since proper prophylaxis remains the best strategy, many scientists have studied the risk factors that may affect AD development. There is robust...

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Autores principales: Leszek, Jerzy, Mikhaylenko, Elizaveta V., Belousov, Dmitrii M., Koutsouraki, Efrosini, Szczechowiak, Katarzyna, Kobusiak-Prokopowicz, Małgorzata, Mysiak, Andrzej, Diniz, Breno Satler, Somasundaram, Siva G., Kirkland, Cecil E., Aliev, Gjumrakch
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033981/
https://www.ncbi.nlm.nih.gov/pubmed/32727331
http://dx.doi.org/10.2174/1570159X18666200729093724
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author Leszek, Jerzy
Mikhaylenko, Elizaveta V.
Belousov, Dmitrii M.
Koutsouraki, Efrosini
Szczechowiak, Katarzyna
Kobusiak-Prokopowicz, Małgorzata
Mysiak, Andrzej
Diniz, Breno Satler
Somasundaram, Siva G.
Kirkland, Cecil E.
Aliev, Gjumrakch
author_facet Leszek, Jerzy
Mikhaylenko, Elizaveta V.
Belousov, Dmitrii M.
Koutsouraki, Efrosini
Szczechowiak, Katarzyna
Kobusiak-Prokopowicz, Małgorzata
Mysiak, Andrzej
Diniz, Breno Satler
Somasundaram, Siva G.
Kirkland, Cecil E.
Aliev, Gjumrakch
author_sort Leszek, Jerzy
collection PubMed
description The root cause of non-inherited Alzheimer’s disease (AD) remains unknown despite hundreds of research studies performed to attempt to solve this problem. Since proper prophylaxis remains the best strategy, many scientists have studied the risk factors that may affect AD development. There is robust evidence supporting the hypothesis that cardiovascular diseases (CVD) may contribute to AD progression, as the diseases often coexist. Therefore, a lack of well-defined diagnostic criteria makes studying the relationship between AD and CVD complicated. Additionally, inflammation accompanies the pathogenesis of AD and CVD, and is not only a consequence but also implicated as a significant contributor to the course of the diseases. Of note, АроЕε4 is found to be one of the major risk factors affecting both the cardiovascular and nervous systems. According to genome wide association and epidemiological studies, numerous common risk factors have been associated with the development of AD-related pathology. Furthermore, the risk of developing AD and CVDs appears to be increased by a wide range of conditions and lifestyle factors: hypertension, dyslipidemia, hypercholesterolemia, hyperhomocysteinemia, gut/oral microbiota, physical activity, and diet. This review summarizes the literature and provides possible mechanistic links between CVDs and AD.
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spelling pubmed-80339812021-08-01 The Links between Cardiovascular Diseases and Alzheimer's Disease Leszek, Jerzy Mikhaylenko, Elizaveta V. Belousov, Dmitrii M. Koutsouraki, Efrosini Szczechowiak, Katarzyna Kobusiak-Prokopowicz, Małgorzata Mysiak, Andrzej Diniz, Breno Satler Somasundaram, Siva G. Kirkland, Cecil E. Aliev, Gjumrakch Curr Neuropharmacol Article The root cause of non-inherited Alzheimer’s disease (AD) remains unknown despite hundreds of research studies performed to attempt to solve this problem. Since proper prophylaxis remains the best strategy, many scientists have studied the risk factors that may affect AD development. There is robust evidence supporting the hypothesis that cardiovascular diseases (CVD) may contribute to AD progression, as the diseases often coexist. Therefore, a lack of well-defined diagnostic criteria makes studying the relationship between AD and CVD complicated. Additionally, inflammation accompanies the pathogenesis of AD and CVD, and is not only a consequence but also implicated as a significant contributor to the course of the diseases. Of note, АроЕε4 is found to be one of the major risk factors affecting both the cardiovascular and nervous systems. According to genome wide association and epidemiological studies, numerous common risk factors have been associated with the development of AD-related pathology. Furthermore, the risk of developing AD and CVDs appears to be increased by a wide range of conditions and lifestyle factors: hypertension, dyslipidemia, hypercholesterolemia, hyperhomocysteinemia, gut/oral microbiota, physical activity, and diet. This review summarizes the literature and provides possible mechanistic links between CVDs and AD. Bentham Science Publishers 2021-02 2021-02 /pmc/articles/PMC8033981/ /pubmed/32727331 http://dx.doi.org/10.2174/1570159X18666200729093724 Text en © 2021 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Leszek, Jerzy
Mikhaylenko, Elizaveta V.
Belousov, Dmitrii M.
Koutsouraki, Efrosini
Szczechowiak, Katarzyna
Kobusiak-Prokopowicz, Małgorzata
Mysiak, Andrzej
Diniz, Breno Satler
Somasundaram, Siva G.
Kirkland, Cecil E.
Aliev, Gjumrakch
The Links between Cardiovascular Diseases and Alzheimer's Disease
title The Links between Cardiovascular Diseases and Alzheimer's Disease
title_full The Links between Cardiovascular Diseases and Alzheimer's Disease
title_fullStr The Links between Cardiovascular Diseases and Alzheimer's Disease
title_full_unstemmed The Links between Cardiovascular Diseases and Alzheimer's Disease
title_short The Links between Cardiovascular Diseases and Alzheimer's Disease
title_sort links between cardiovascular diseases and alzheimer's disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033981/
https://www.ncbi.nlm.nih.gov/pubmed/32727331
http://dx.doi.org/10.2174/1570159X18666200729093724
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