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The phospholipase D inhibitor FIPI potently blocks EGF-induced calcium signaling in human breast cancer cells

BACKGROUND: Phosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for several cellular processes, including cell migration. However, PLC-γ1 could also be...

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Detalles Bibliográficos
Autores principales:	Stricker, Helena M., Rommerswinkel, Nadine, Keil, Silvia, Gnoth, Sandina A., Niggemann, Bernd, Dittmar, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034102/ https://www.ncbi.nlm.nih.gov/pubmed/33832505 http://dx.doi.org/10.1186/s12964-021-00724-z

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