Cargando…

Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer

Breast cancer (BC) is a highly heterogeneous disease encompassing multiple subtypes with different molecular and histopathological features, disease prognosis, and therapeutic responses. Among these, the Triple Negative BC form (TNBC) is an aggressive subtype with poor prognosis and therapeutic outc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Orfanou, Ioanna-Maria, Argyros, Orestis, Papapetropoulos, Andreas, Tseleni-Balafouta, Sofia, Vougas, Konstantinos, Tamvakopoulos, Constantin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034292/ https://www.ncbi.nlm.nih.gov/pubmed/33842315 http://dx.doi.org/10.3389/fonc.2021.608201

Ejemplares similares

Targeting STEAP1 as an anticancer strategy
por: Nakamura, Hajime, et al.
Publicado: (2023)

Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule
por: Argyros, Orestis, et al.
Publicado: (2017)

Laser-Induced Forward Transfer Printing on Microneedles for Transdermal Delivery of Gemcitabine
por: Kanaki, Zoi, et al.
Publicado: (2022)

Lessons learned from the management of Hungry Bone Syndrome following the removal of an Atypical Parathyroid Adenoma
por: Florakis, Dimos, et al.
Publicado: (2019)

Expression and prognostic analyses of the significance of STEAP1 and STEAP2 in lung cancer
por: Liu, Tianshu, et al.
Publicado: (2022)

Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms
por: Gomes, Inês M., et al.
Publicado: (2014)

Upregulation of the ferroptosis-related STEAP3 gene is a specific predictor of poor triple-negative breast cancer patient outcomes
por: Yuan, Lifang, et al.
Publicado: (2023)

De-escalated radiotherapy for HER2-overexpressing breast cancer patients with 1-3 positive lymph nodes undergoing anti-HER2 targeted therapy
por: Liu, Jing, et al.
Publicado: (2023)

Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
por: Manatakis, Dimitrios K., et al.
Publicado: (2017)

Breast Cancer With a HER2 IHC2+ and FISH HER2/CEP17 Ratio ≥2.0 and an Average HER2 Gene Copy Number <4.0 per Tumor Cell: HER2 mRNA Overexpression Is a Rare Event
por: Liu, Yuanyuan, et al.
Publicado: (2020)

Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1– Mediated Gemcitabine Chemoresistance
por: Bai, Zhiqing, et al.
Publicado: (2022)

HER2 status in recurrent/metastatic androgen receptor overexpressing salivary gland carcinoma patients
por: Cavalieri, Stefano, et al.
Publicado: (2023)

Efficacy of Pyrotinib in HER2-Overexpressing Salivary Duct Carcinoma With Lung Metastasis: A Case Report
por: Yang, Zi-yan, et al.
Publicado: (2020)

A Molecular Docking Study of Human STEAP2 for the Discovery of New Potential Anti-Prostate Cancer Chemotherapeutic Candidates
por: Ongaba, Timothy, et al.
Publicado: (2022)

Comparative review of pharmacological therapies in individuals with HER2-positive advanced breast cancer with focus on hormone receptor subgroups
por: Umemneku-Chikere, Chinyereugo M., et al.
Publicado: (2022)

STEAP1 expression in prostate cancer and its regulation by androgens
por: Gomes, Inês, et al.
Publicado: (2010)

Clinical significance of STEAP1 extracellular vesicles in prostate cancer
por: Khanna, Karan, et al.
Publicado: (2021)

lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer
por: Na, Heya, et al.
Publicado: (2020)

The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer
por: Wu, Hua-Tao, et al.
Publicado: (2020)

18-Fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography scan for monitoring the therapeutic response in experimental Staphylococcus aureus foreign-body osteomyelitis
por: Chatziioannou, Sofia, et al.
Publicado: (2015)

STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells
por: Burnell, Stephanie E. A., et al.
Publicado: (2018)

EIF4E regulates STEAP1 expression in peritoneal metastasis
por: Jiang, Jun-nan, et al.
Publicado: (2020)

The expression of STEAP4 in peripheral blood predicts the outcome of septic patients
por: Jiang, Haiyan, et al.
Publicado: (2021)

Case Report: Effective Treatment With Pyrotinib and Capecitabine in a Heavily Pretreated Locally Advanced Breast Cancer Harboring Both HER2 Overexpression and Mutant
por: Gao, Zhichao, et al.
Publicado: (2021)

STEAP1 Regulates Tumorigenesis and Chemoresistance During Peritoneal Metastasis of Gastric Cancer
por: Wu, Yuan-Yu, et al.
Publicado: (2018)

Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing’s Sarcoma
por: Markey, Fatu Badiane, et al.
Publicado: (2021)

The copper-associated protein STEAP2 correlated with glioma prognosis and immune infiltration
por: Wang, Xu, et al.
Publicado: (2022)

Identification of STEAP3-based molecular subtype and risk model in ovarian cancer
por: Zhao, Zouyu, et al.
Publicado: (2023)

Discovery of therapeutic targets of quercetin for endometrial carcinoma patients infected with COVID-19 through network pharmacology
por: Li, Kehan, et al.
Publicado: (2023)

UBE2C Overexpression Aggravates Patient Outcome by Promoting Estrogen-Dependent/Independent Cell Proliferation in Early Hormone Receptor-Positive and HER2-Negative Breast Cancer
por: Kim, Yu-Jin, et al.
Publicado: (2020)

Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres
por: Manatakis, Dimitrios K., et al.
Publicado: (2018)

Immunotherapy for HER-2 positive breast cancer
por: Yang, Tingting, et al.
Publicado: (2023)

Preclinical HER-2 Vaccines: From Rodent to Human HER-2
por: Lollini, Pier-Luigi, et al.
Publicado: (2013)

Immune microenvironment dynamics of HER2 overexpressing breast cancer under dual anti-HER2 blockade
por: Batalha, Sofia, et al.
Publicado: (2023)

Steap4 attenuates high glucose and S100B-induced effects in mesangial cells
por: Chuang, Chao-Tang, et al.
Publicado: (2015)

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction
por: Oosterheert, Wout, et al.
Publicado: (2018)

Novel potent anti-STEAP1 bispecific antibody to redirect T cells for cancer immunotherapy
por: Lin, Tsung-Yi, et al.
Publicado: (2021)

STEAP1 Knockdown Decreases the Sensitivity of Prostate Cancer Cells to Paclitaxel, Docetaxel and Cabazitaxel
por: Rocha, Sandra M., et al.
Publicado: (2023)

Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m(6)A-mediated degradation of STEAP3 mRNA
por: Zhou, Li, et al.
Publicado: (2022)

Optimal Duration of Neoadjuvant Taxane and Carboplatin Combined With Anti-HER2 Targeted Therapy for HER2-Positive Breast Cancer
por: Xie, Yifan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3jplh86pgku0nini3q0g1lgchb