Cargando…

TTN/OBSCN ‘Double‐Hit’ predicts favourable prognosis, ‘immune‐hot’ subtype and potentially better immunotherapeutic efficacy in colorectal cancer

Colorectal cancer (CRC) remains a leading cause of cancer‐related deaths worldwide. Although treatment strategies for solid tumours have been revolutionized by immunotherapy, only a small subset of CRC patients benefit. Using two‐independent cohorts, we found the common frequently mutated genes TTN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zaoqu, Wang, Libo, Guo, Chunguang, Liu, Long, Jiao, Dechao, Sun, Zhenqiang, Wu, Kunpeng, Zhao, Yanan, Han, Xinwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034451/ https://www.ncbi.nlm.nih.gov/pubmed/33624434 http://dx.doi.org/10.1111/jcmm.16393

Ejemplares similares

Association of RYR2 Mutation With Tumor Mutation Burden, Prognosis, and Antitumor Immunity in Patients With Esophageal Adenocarcinoma
por: Liu, Zaoqu, et al.
Publicado: (2021)

Somatic mutations in homologous recombination pathway predict favourable prognosis after immunotherapy across multiple cancer types
por: Liu, Zaoqu, et al.
Publicado: (2021)

OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency
por: Marston, Steven, et al.
Publicado: (2015)

OBSCN restoration via OBSCN-AS1 long-noncoding RNA CRISPR-targeting suppresses metastasis in triple-negative breast cancer
por: Guardia, Talia, et al.
Publicado: (2023)

The Identification and Validation of Two Heterogenous Subtypes and a Risk Signature Based on Ferroptosis in Hepatocellular Carcinoma
por: Liu, Zaoqu, et al.
Publicado: (2021)

Clinical Significance and Inflammatory Landscape of aNovel Recurrence-Associated Immune Signature in Stage II/III Colorectal Cancer
por: Liu, Zaoqu, et al.
Publicado: (2021)

Development and clinical validation of a novel six-gene signature for accurately predicting the recurrence risk of patients with stage II/III colorectal cancer
por: Liu, Zaoqu, et al.
Publicado: (2021)

PI3K pathway mutation predicts an activated immune microenvironment and better immunotherapeutic efficacy in head and neck squamous cell carcinoma
por: Wang, Libo, et al.
Publicado: (2023)

Genomic Alteration Characterization in Colorectal Cancer Identifies a Prognostic and Metastasis Biomarker: FAM83A|IDO1
por: Liu, Zaoqu, et al.
Publicado: (2021)

Establishment and experimental validation of an immune miRNA signature for assessing prognosis and immune landscape of patients with colorectal cancer
por: Liu, Zaoqu, et al.
Publicado: (2021)

Editorial: Application of artificial intelligence in improving immunotherapeutic efficacy
por: Li, Jie, et al.
Publicado: (2022)

CELF2 is a candidate prognostic and immunotherapy biomarker in triple‐negative breast cancer and lung squamous cell carcinoma: A pan‐cancer analysis
por: Wang, Libo, et al.
Publicado: (2021)

A novel FLNC frameshift and an OBSCN variant in a family with distal muscular dystrophy
por: Rossi, Daniela, et al.
Publicado: (2017)

Immune perturbation network identifies an EMT subtype with chromosomal instability and tumor immune-desert microenvironment
por: Xu, Hui, et al.
Publicado: (2023)

Integrative analysis from multi-center studies identities a consensus machine learning-derived lncRNA signature for stage II/III colorectal cancer
por: Liu, Zaoqu, et al.
Publicado: (2021)

Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer
por: Liu, Zaoqu, et al.
Publicado: (2022)

A comprehensive genomic meta-analysis identifies confirmatory role of OBSCN gene in breast tumorigenesis
por: Rajendran, Barani Kumar, et al.
Publicado: (2017)

Hypoxia Molecular Characterization in Hepatocellular Carcinoma Identifies One Risk Signature and Two Nomograms for Clinical Management
por: Liu, Zaoqu, et al.
Publicado: (2021)

A novel immune classification reveals distinct immune escape mechanism and genomic alterations: implications for immunotherapy in hepatocellular carcinoma
por: Liu, Zaoqu, et al.
Publicado: (2021)

Effect of TTN Mutations on Immune Microenvironment and Efficacy of Immunotherapy in Lung Adenocarcinoma Patients
por: Wang, Zhe, et al.
Publicado: (2021)

A Comparative Study of Self-Expandable Metallic Stent Combined with Double (125)I Seeds Strands or Single (125)I Seeds Strand in the Treatment of Advanced Perihilar Cholangiocarcinoma with Malignant Obstructive Jaundice
por: Li, Zhaonan, et al.
Publicado: (2021)

Gene interaction perturbation network deciphers a high-resolution taxonomy in colorectal cancer
por: Liu, Zaoqu, et al.
Publicado: (2022)

CRISPR-Cas9 identifies growth-related subtypes of glioblastoma with therapeutical significance through cell line knockdown
por: Zhao, Nannan, et al.
Publicado: (2023)

Long noncoding RNA TTN-AS1 facilitates tumorigenesis and metastasis by maintaining TTN expression in skin cutaneous melanoma
por: Wang, Ying, et al.
Publicado: (2020)

Integrative pharmacogenomics revealed three subtypes with different immune landscapes and specific therapeutic responses in lung adenocarcinoma
por: Ge, Xiaoyong, et al.
Publicado: (2022)

Intracellular calcium current disorder and disease phenotype in OBSCN mutant iPSC-based cardiomyocytes in arrhythmogenic right ventricular cardiomyopathy
por: Chen, Peipei, et al.
Publicado: (2020)

Editorial: The role of multi-omics variants in tumor immunity and immunotherapy
por: Chen, Shuang, et al.
Publicado: (2022)

Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment
por: Xu, Hui, et al.
Publicado: (2022)

MR-guided microwave ablation of hepatocellular carcinoma (HCC): is general anesthesia more effective than local anesthesia?
por: Li, Zhaonan, et al.
Publicado: (2021)

LINC00680 and TTN-AS1 Stabilized by EIF4A3 Promoted Malignant Biological Behaviors of Glioblastoma Cells
por: Tang, Wei, et al.
Publicado: (2019)

Multi-omics landscape and clinical significance of a SMAD4-driven immune signature: Implications for risk stratification and frontline therapies in pancreatic cancer
por: Wang, Libo, et al.
Publicado: (2022)

Immunosenescence: molecular mechanisms and diseases
por: Liu, Zaoqu, et al.
Publicado: (2023)

Prognostic significance of long noncoding RNA TTN‐AS1 in various malignancies
por: Lin, Guangyao, et al.
Publicado: (2023)

Editorial: Using multi-omics to develop new strategies to improve prognosis and immunotherapy outcomes in cancers
por: Cao, Chenxi, et al.
Publicado: (2023)

Radiotherapy remodels the tumor microenvironment for enhancing immunotherapeutic sensitivity
por: Liu, Senbo, et al.
Publicado: (2023)

TTN mutations predict a poor prognosis in patients with thyroid cancer
por: Han, Xiudan, et al.
Publicado: (2022)

2450-MHz microwave ablation of liver metastases under 3.0 T wide-bore magnetic resonance guidance: a pilot study
por: Xu, Kaihao, et al.
Publicado: (2022)

Epigenetically regulated gene expression profiles decipher four molecular subtypes with prognostic and therapeutic implications in gastric cancer
por: Weng, Siyuan, et al.
Publicado: (2023)

Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103(+)CD8(+) T cells conferring favourable prognosis
por: Li, Ruochen, et al.
Publicado: (2020)

Construction of a TTN Mutation-Based Prognostic Model for Evaluating Immune Microenvironment, Cancer Stemness, and Outcomes of Colorectal Cancer Patients
por: Zhao, Lei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jt7ongh3d92pcpa70p7glo44qq