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m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis
The role of epigenetic regulation in immunity is emerging, especially for RNA N6‐methyladenosine (m6A) modification. However, little is known about the role of m6A in the regulation of the immune microenvironment of periodontitis. Thus, we aim to investigate the impact of m6A modification in periodo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034465/ https://www.ncbi.nlm.nih.gov/pubmed/33724691 http://dx.doi.org/10.1111/jcmm.16469 |
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author | Zhang, Xiaoqi Zhang, Shizhen Yan, Xinyu Shan, Yue Liu, Lu Zhou, Jing Kuang, Qianyun Li, Minqi Long, Hu Lai, Wenli |
author_facet | Zhang, Xiaoqi Zhang, Shizhen Yan, Xinyu Shan, Yue Liu, Lu Zhou, Jing Kuang, Qianyun Li, Minqi Long, Hu Lai, Wenli |
author_sort | Zhang, Xiaoqi |
collection | PubMed |
description | The role of epigenetic regulation in immunity is emerging, especially for RNA N6‐methyladenosine (m6A) modification. However, little is known about the role of m6A in the regulation of the immune microenvironment of periodontitis. Thus, we aim to investigate the impact of m6A modification in periodontitis immune microenvironment. The RNA modification patterns mediated by 23 m6A‐regulators were systematically evaluated in 310 periodontitis samples. The impact of m6A modification on immune microenvironment characteristics was explored, including infiltrating immunocytes, immune reaction gene‐sets and HLAs (human leukocyte antigen) gene. m6A phenotype‐related immune genes were also identified. 17 m6A regulators were dysregulated and a 15‐m6A regulator signature can well distinguish periodontitis and control samples. ALKBH5 and FMR1 are closely related to infiltrating monocyte abundance. ELAVL1 and CBLL1 are significant regulators in immune reaction of TNF_Family_Members_Receptors and Cytokine. The expression of HLA‐B and HLA‐DOA is affected by ALKBH5 and LRPPRC. 3 distinct RNA modification patterns mediated by 23 m6A regulators were identified. They differ from immunocyte abundance, immune reaction and HLA gene. 1631 m6A phenotype‐related genes and 70 m6A‐mediated immune genes were identified, and the biological functions of these were explored. Our finding demonstrated the m6A modification plays a crucial role in the diversity and complexity of the immune microenvironment of periodontitis. |
format | Online Article Text |
id | pubmed-8034465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80344652021-04-14 m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis Zhang, Xiaoqi Zhang, Shizhen Yan, Xinyu Shan, Yue Liu, Lu Zhou, Jing Kuang, Qianyun Li, Minqi Long, Hu Lai, Wenli J Cell Mol Med Original Articles The role of epigenetic regulation in immunity is emerging, especially for RNA N6‐methyladenosine (m6A) modification. However, little is known about the role of m6A in the regulation of the immune microenvironment of periodontitis. Thus, we aim to investigate the impact of m6A modification in periodontitis immune microenvironment. The RNA modification patterns mediated by 23 m6A‐regulators were systematically evaluated in 310 periodontitis samples. The impact of m6A modification on immune microenvironment characteristics was explored, including infiltrating immunocytes, immune reaction gene‐sets and HLAs (human leukocyte antigen) gene. m6A phenotype‐related immune genes were also identified. 17 m6A regulators were dysregulated and a 15‐m6A regulator signature can well distinguish periodontitis and control samples. ALKBH5 and FMR1 are closely related to infiltrating monocyte abundance. ELAVL1 and CBLL1 are significant regulators in immune reaction of TNF_Family_Members_Receptors and Cytokine. The expression of HLA‐B and HLA‐DOA is affected by ALKBH5 and LRPPRC. 3 distinct RNA modification patterns mediated by 23 m6A regulators were identified. They differ from immunocyte abundance, immune reaction and HLA gene. 1631 m6A phenotype‐related genes and 70 m6A‐mediated immune genes were identified, and the biological functions of these were explored. Our finding demonstrated the m6A modification plays a crucial role in the diversity and complexity of the immune microenvironment of periodontitis. John Wiley and Sons Inc. 2021-03-16 2021-04 /pmc/articles/PMC8034465/ /pubmed/33724691 http://dx.doi.org/10.1111/jcmm.16469 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Zhang, Xiaoqi Zhang, Shizhen Yan, Xinyu Shan, Yue Liu, Lu Zhou, Jing Kuang, Qianyun Li, Minqi Long, Hu Lai, Wenli m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis |
title | m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis |
title_full | m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis |
title_fullStr | m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis |
title_full_unstemmed | m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis |
title_short | m6A regulator‐mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis |
title_sort | m6a regulator‐mediated rna methylation modification patterns are involved in immune microenvironment regulation of periodontitis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034465/ https://www.ncbi.nlm.nih.gov/pubmed/33724691 http://dx.doi.org/10.1111/jcmm.16469 |
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