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PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective
Osteosarcoma occurs largely in children and adolescents and is the most common primary malignant tumour of bone. Although surgical advances and neoadjuvant chemotherapy have made great strides in recent years, rates of local recurrence and lung metastasis remain high, with a plateau in overall survi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034476/ https://www.ncbi.nlm.nih.gov/pubmed/33675132 http://dx.doi.org/10.1111/jcmm.16420 |
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author | Sun, Chaonan Li, Shenglong |
author_facet | Sun, Chaonan Li, Shenglong |
author_sort | Sun, Chaonan |
collection | PubMed |
description | Osteosarcoma occurs largely in children and adolescents and is the most common primary malignant tumour of bone. Although surgical advances and neoadjuvant chemotherapy have made great strides in recent years, rates of local recurrence and lung metastasis remain high, with a plateau in overall survival during the past decade. It is thus urgent to explore the pathogenesis of osteosarcoma and identify potential therapeutic targets. Parathyroid hormone receptor 1 (PTHR1) belongs to the broad family of G protein–coupled receptors, binding both parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP, a paracrine factor). Previous studies have shown that in tissues and cells of osteosarcoma, expression of PTHR1 is markedly increased, correlating with aggressive biologic behaviour and a poor prognosis. PTHR1 expression also correlates closely with epigenetic regulation, transcriptional regulation, post‐translational modification and protein interaction. Herein, we have summarized the latest research on the role played by PTHR1 in progression of osteosarcoma, assessing its clinical utility as a novel biomarker and its therapeutic ramifications. |
format | Online Article Text |
id | pubmed-8034476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80344762021-04-14 PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective Sun, Chaonan Li, Shenglong J Cell Mol Med Review Osteosarcoma occurs largely in children and adolescents and is the most common primary malignant tumour of bone. Although surgical advances and neoadjuvant chemotherapy have made great strides in recent years, rates of local recurrence and lung metastasis remain high, with a plateau in overall survival during the past decade. It is thus urgent to explore the pathogenesis of osteosarcoma and identify potential therapeutic targets. Parathyroid hormone receptor 1 (PTHR1) belongs to the broad family of G protein–coupled receptors, binding both parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP, a paracrine factor). Previous studies have shown that in tissues and cells of osteosarcoma, expression of PTHR1 is markedly increased, correlating with aggressive biologic behaviour and a poor prognosis. PTHR1 expression also correlates closely with epigenetic regulation, transcriptional regulation, post‐translational modification and protein interaction. Herein, we have summarized the latest research on the role played by PTHR1 in progression of osteosarcoma, assessing its clinical utility as a novel biomarker and its therapeutic ramifications. John Wiley and Sons Inc. 2021-03-06 2021-04 /pmc/articles/PMC8034476/ /pubmed/33675132 http://dx.doi.org/10.1111/jcmm.16420 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Sun, Chaonan Li, Shenglong PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective |
title | PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective |
title_full | PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective |
title_fullStr | PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective |
title_full_unstemmed | PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective |
title_short | PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective |
title_sort | pthr1 in osteosarcoma: specific molecular mechanisms and comprehensive functional perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034476/ https://www.ncbi.nlm.nih.gov/pubmed/33675132 http://dx.doi.org/10.1111/jcmm.16420 |
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