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PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective

Osteosarcoma occurs largely in children and adolescents and is the most common primary malignant tumour of bone. Although surgical advances and neoadjuvant chemotherapy have made great strides in recent years, rates of local recurrence and lung metastasis remain high, with a plateau in overall survi...

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Detalles Bibliográficos
Autores principales: Sun, Chaonan, Li, Shenglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034476/
https://www.ncbi.nlm.nih.gov/pubmed/33675132
http://dx.doi.org/10.1111/jcmm.16420
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author Sun, Chaonan
Li, Shenglong
author_facet Sun, Chaonan
Li, Shenglong
author_sort Sun, Chaonan
collection PubMed
description Osteosarcoma occurs largely in children and adolescents and is the most common primary malignant tumour of bone. Although surgical advances and neoadjuvant chemotherapy have made great strides in recent years, rates of local recurrence and lung metastasis remain high, with a plateau in overall survival during the past decade. It is thus urgent to explore the pathogenesis of osteosarcoma and identify potential therapeutic targets. Parathyroid hormone receptor 1 (PTHR1) belongs to the broad family of G protein–coupled receptors, binding both parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP, a paracrine factor). Previous studies have shown that in tissues and cells of osteosarcoma, expression of PTHR1 is markedly increased, correlating with aggressive biologic behaviour and a poor prognosis. PTHR1 expression also correlates closely with epigenetic regulation, transcriptional regulation, post‐translational modification and protein interaction. Herein, we have summarized the latest research on the role played by PTHR1 in progression of osteosarcoma, assessing its clinical utility as a novel biomarker and its therapeutic ramifications.
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spelling pubmed-80344762021-04-14 PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective Sun, Chaonan Li, Shenglong J Cell Mol Med Review Osteosarcoma occurs largely in children and adolescents and is the most common primary malignant tumour of bone. Although surgical advances and neoadjuvant chemotherapy have made great strides in recent years, rates of local recurrence and lung metastasis remain high, with a plateau in overall survival during the past decade. It is thus urgent to explore the pathogenesis of osteosarcoma and identify potential therapeutic targets. Parathyroid hormone receptor 1 (PTHR1) belongs to the broad family of G protein–coupled receptors, binding both parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP, a paracrine factor). Previous studies have shown that in tissues and cells of osteosarcoma, expression of PTHR1 is markedly increased, correlating with aggressive biologic behaviour and a poor prognosis. PTHR1 expression also correlates closely with epigenetic regulation, transcriptional regulation, post‐translational modification and protein interaction. Herein, we have summarized the latest research on the role played by PTHR1 in progression of osteosarcoma, assessing its clinical utility as a novel biomarker and its therapeutic ramifications. John Wiley and Sons Inc. 2021-03-06 2021-04 /pmc/articles/PMC8034476/ /pubmed/33675132 http://dx.doi.org/10.1111/jcmm.16420 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sun, Chaonan
Li, Shenglong
PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective
title PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective
title_full PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective
title_fullStr PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective
title_full_unstemmed PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective
title_short PTHR1 in osteosarcoma: Specific molecular mechanisms and comprehensive functional perspective
title_sort pthr1 in osteosarcoma: specific molecular mechanisms and comprehensive functional perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034476/
https://www.ncbi.nlm.nih.gov/pubmed/33675132
http://dx.doi.org/10.1111/jcmm.16420
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