Cargando…
De novo 3D models of SARS-CoV-2 RNA elements from consensus experimental secondary structures
The rapid spread of COVID-19 is motivating development of antivirals targeting conserved SARS-CoV-2 molecular machinery. The SARS-CoV-2 genome includes conserved RNA elements that offer potential small-molecule drug targets, but most of their 3D structures have not been experimentally characterized....
Autores principales: | Rangan, Ramya, Watkins, Andrew M, Chacon, Jose, Kretsch, Rachael, Kladwang, Wipapat, Zheludev, Ivan N, Townley, Jill, Rynge, Mats, Thain, Gregory, Das, Rhiju |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034642/ https://www.ncbi.nlm.nih.gov/pubmed/33693814 http://dx.doi.org/10.1093/nar/gkab119 |
Ejemplares similares
-
RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses
por: Rangan, Ramya, et al.
Publicado: (2020) -
Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures
por: Kappel, Kalli, et al.
Publicado: (2020) -
Ultraviolet Shadowing of RNA Can Cause Significant Chemical Damage in Seconds
por: Kladwang, Wipapat, et al.
Publicado: (2012) -
Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping
por: Tian, Siqi, et al.
Publicado: (2018) -
High-throughput mutate-map-rescue evaluates SHAPE-directed RNA structure and uncovers excited states
por: Tian, Siqi, et al.
Publicado: (2014)