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Reactive astrocytes in ALS display diminished intron retention

Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human-induced pluripotent stem cell (hiPSC)-derived astrocytes carrying ALS-causing mutations...

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Detalles Bibliográficos
Autores principales:	Ziff, Oliver J, Taha, Doaa M, Crerar, Hamish, Clarke, Benjamin E, Chakrabarti, Anob M, Kelly, Gavin, Neeves, Jacob, Tyzack, Giulia E, Luscombe, Nicholas M, Patani, Rickie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Data Resources and Analyses
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034657/ https://www.ncbi.nlm.nih.gov/pubmed/33684213 http://dx.doi.org/10.1093/nar/gkab115

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