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Impact of subdivision of pathological stage I colorectal cancer
AIM: Stage II‐IV colorectal cancers are subdivided according to TNM categories. However, stage I cases are a single category, despite the inclusion of both T1 and T2 cases, which may have different outcomes. The aim of this study was to evaluate the usefulness of subdividing stage I colorectal cance...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034690/ https://www.ncbi.nlm.nih.gov/pubmed/33860143 http://dx.doi.org/10.1002/ags3.12407 |
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author | Fujii, Shoichi Shimada, Ryu Tsukamoto, Mitsuo Hayama, Tamuro Ishibe, Atsushi Watanabe, Jun Deguchi, Takashi Tsutsumi, Kenji Matsuda, Keiji Hashiguchi, Yojiro |
author_facet | Fujii, Shoichi Shimada, Ryu Tsukamoto, Mitsuo Hayama, Tamuro Ishibe, Atsushi Watanabe, Jun Deguchi, Takashi Tsutsumi, Kenji Matsuda, Keiji Hashiguchi, Yojiro |
author_sort | Fujii, Shoichi |
collection | PubMed |
description | AIM: Stage II‐IV colorectal cancers are subdivided according to TNM categories. However, stage I cases are a single category, despite the inclusion of both T1 and T2 cases, which may have different outcomes. The aim of this study was to evaluate the usefulness of subdividing stage I colorectal cancers by T category. METHODS: From 1984 to 2015, 844 patients with stage I colorectal cancer (T1: 446, T2: 398) underwent colorectal resection with lymph node dissection at three hospitals. The long‐term survival and recurrence rates were compared between T1 and T2. A Cox regression analysis was used to evaluate the risk factors associated with cancer recurrence. RESULTS: A comparison of the T1 and T2 groups revealed significant differences in 5‐year overall (95.9% vs 91.4%, P = .008), recurrence‐free (94.8% vs 87.1%, P = .0007), and cancer‐specific survival (97.6% vs 93.6%, P = .004), and in the overall (2.5% vs 6.8%, P = .003), local (0.2% vs 1.5%, P = .04), and lymph node recurrence rates (0.2% vs 1.5%, P = .04). All local and lymph node recurrences were associated with lower rectal cancer, and this difference was significant. The Cox multivariate analysis identified male sex (P = .01, hazard ratio: 4.00, 95% confidence interval: 1.38‐11.55), T2 (P = .02, hazard ratio: 2.98, 95% confidence interval: 1.17‐7.60), and venous invasion (P = .03, hazard ratio: 2.38, 95% confidence interval: 1.12‐5.10) as risk factors for recurrence. CONCLUSIONS: The subdivision of stage I colorectal cancer according to T category clearly reflected the long‐term outcomes. |
format | Online Article Text |
id | pubmed-8034690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80346902021-04-14 Impact of subdivision of pathological stage I colorectal cancer Fujii, Shoichi Shimada, Ryu Tsukamoto, Mitsuo Hayama, Tamuro Ishibe, Atsushi Watanabe, Jun Deguchi, Takashi Tsutsumi, Kenji Matsuda, Keiji Hashiguchi, Yojiro Ann Gastroenterol Surg Original Articles AIM: Stage II‐IV colorectal cancers are subdivided according to TNM categories. However, stage I cases are a single category, despite the inclusion of both T1 and T2 cases, which may have different outcomes. The aim of this study was to evaluate the usefulness of subdividing stage I colorectal cancers by T category. METHODS: From 1984 to 2015, 844 patients with stage I colorectal cancer (T1: 446, T2: 398) underwent colorectal resection with lymph node dissection at three hospitals. The long‐term survival and recurrence rates were compared between T1 and T2. A Cox regression analysis was used to evaluate the risk factors associated with cancer recurrence. RESULTS: A comparison of the T1 and T2 groups revealed significant differences in 5‐year overall (95.9% vs 91.4%, P = .008), recurrence‐free (94.8% vs 87.1%, P = .0007), and cancer‐specific survival (97.6% vs 93.6%, P = .004), and in the overall (2.5% vs 6.8%, P = .003), local (0.2% vs 1.5%, P = .04), and lymph node recurrence rates (0.2% vs 1.5%, P = .04). All local and lymph node recurrences were associated with lower rectal cancer, and this difference was significant. The Cox multivariate analysis identified male sex (P = .01, hazard ratio: 4.00, 95% confidence interval: 1.38‐11.55), T2 (P = .02, hazard ratio: 2.98, 95% confidence interval: 1.17‐7.60), and venous invasion (P = .03, hazard ratio: 2.38, 95% confidence interval: 1.12‐5.10) as risk factors for recurrence. CONCLUSIONS: The subdivision of stage I colorectal cancer according to T category clearly reflected the long‐term outcomes. John Wiley and Sons Inc. 2020-11-11 /pmc/articles/PMC8034690/ /pubmed/33860143 http://dx.doi.org/10.1002/ags3.12407 Text en © 2020 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Fujii, Shoichi Shimada, Ryu Tsukamoto, Mitsuo Hayama, Tamuro Ishibe, Atsushi Watanabe, Jun Deguchi, Takashi Tsutsumi, Kenji Matsuda, Keiji Hashiguchi, Yojiro Impact of subdivision of pathological stage I colorectal cancer |
title | Impact of subdivision of pathological stage I colorectal cancer |
title_full | Impact of subdivision of pathological stage I colorectal cancer |
title_fullStr | Impact of subdivision of pathological stage I colorectal cancer |
title_full_unstemmed | Impact of subdivision of pathological stage I colorectal cancer |
title_short | Impact of subdivision of pathological stage I colorectal cancer |
title_sort | impact of subdivision of pathological stage i colorectal cancer |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034690/ https://www.ncbi.nlm.nih.gov/pubmed/33860143 http://dx.doi.org/10.1002/ags3.12407 |
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