Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells

Expression of tryptophan 2,3-dioxygenase (TDO) is a determinant of malignancy in gliomas through kynurenine (KYN) signaling. We report that inhibition of TDO activity attenuated recovery from replication stress and increased the genotoxic effects of bis-chloroethylnitrosourea (BCNU). Activation of t...

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Detalles Bibliográficos
Autores principales: Reed, Megan R, Maddukuri, Leena, Ketkar, Amit, Byrum, Stephanie D, Zafar, Maroof K, Bostian, April C L, Tackett, Alan J, Eoff, Robert L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034706/
https://www.ncbi.nlm.nih.gov/pubmed/33870196
http://dx.doi.org/10.1093/narcan/zcab014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034706/
https://www.ncbi.nlm.nih.gov/pubmed/33870196
http://dx.doi.org/10.1093/narcan/zcab014

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