Cargando…

Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells

Expression of tryptophan 2,3-dioxygenase (TDO) is a determinant of malignancy in gliomas through kynurenine (KYN) signaling. We report that inhibition of TDO activity attenuated recovery from replication stress and increased the genotoxic effects of bis-chloroethylnitrosourea (BCNU). Activation of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reed, Megan R, Maddukuri, Leena, Ketkar, Amit, Byrum, Stephanie D, Zafar, Maroof K, Bostian, April C L, Tackett, Alan J, Eoff, Robert L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034706/ https://www.ncbi.nlm.nih.gov/pubmed/33870196 http://dx.doi.org/10.1093/narcan/zcab014

Ejemplares similares

NAD(+) bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells
por: Li, Jianfeng, et al.
Publicado: (2021)

APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response
por: Conner, Kayla L, et al.
Publicado: (2020)

Ku–DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks
por: Mendoza-Munoz, Pamela L, et al.
Publicado: (2023)

CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination
por: Brown, Victoria E, et al.
Publicado: (2023)

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
por: Eckelmann, Bradley J, et al.
Publicado: (2020)

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
por: Jenkins, Tabitha, et al.
Publicado: (2021)

Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and S(N)1 chemotherapeutic agents
por: Armijo, Amanda L, et al.
Publicado: (2023)

Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling
por: Dibitetto, Diego, et al.
Publicado: (2020)

Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma
por: Armstrong, Chris W D, et al.
Publicado: (2020)

Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells
por: Luo, Ang, et al.
Publicado: (2020)

Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses
por: Sharma, Neelam, et al.
Publicado: (2020)

DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions
por: Yu, Zhenbao, et al.
Publicado: (2020)

Defining the mutation signatures of DNA polymerase θ in cancer genomes
por: Hwang, Taejoo, et al.
Publicado: (2020)

Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA damage response
por: Liddiard, Kate, et al.
Publicado: (2021)

Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency
por: Kumar, Rashmi J, et al.
Publicado: (2020)

Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response
por: Zhu, Xiaolan, et al.
Publicado: (2021)

SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma
por: Kurashima, Kiminori, et al.
Publicado: (2020)

Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer
por: Wiegmans, Adrian P, et al.
Publicado: (2021)

Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity
por: Gayle, Sophia, et al.
Publicado: (2021)

The DNA damage inducible lncRNA SCAT7 regulates genomic integrity and topoisomerase 1 turnover in lung adenocarcinoma
por: Statello, Luisa, et al.
Publicado: (2021)

Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development
por: Park, Vivian S, et al.
Publicado: (2022)

High replication stress and limited Rad51-mediated DNA repair capacity, but not oxidative stress, underlie oligodendrocyte precursor cell radiosensitivity
por: Berger, N Daniel, et al.
Publicado: (2022)

The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
por: Safavi, Shiva, et al.
Publicado: (2020)

High-throughput screen to identify compounds that prevent or target telomere loss in human cancer cells
por: Wilson, Chris, et al.
Publicado: (2022)

The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells
por: Vickridge, Elise, et al.
Publicado: (2022)

Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance
por: Channathodiyil, Prasanna, et al.
Publicado: (2022)

ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe
por: Heyza, Joshua R, et al.
Publicado: (2023)

EEPD1 promotes repair of oxidatively-stressed replication forks
por: Jaiswal, Aruna S, et al.
Publicado: (2023)

The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity
por: Labrousse, Guillaume, et al.
Publicado: (2023)

Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
por: Golder, Anya, et al.
Publicado: (2022)

Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors
por: Bhat, Divya S, et al.
Publicado: (2023)

Specificity of cancer-related chromosomal translocations is linked to proximity after the DNA double-strand break and subsequent selection
por: Canoy, Reynand Jay, et al.
Publicado: (2023)

Large-scale phenogenomic analysis of human cancers uncovers frequent alterations affecting SMC5/6 complex components in breast cancer
por: Roy, Shamayita, et al.
Publicado: (2023)

Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors
por: Wie, Minwoo, et al.
Publicado: (2023)

Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma
por: Benada, Jan, et al.
Publicado: (2023)

Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy
por: Slyskova, Jana, et al.
Publicado: (2023)

The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa
por: Maddukuri, Leena, et al.
Publicado: (2014)

Human Rev1 polymerase disrupts G-quadruplex DNA
por: Eddy, Sarah, et al.
Publicado: (2014)

DNA damage recognition /
Publicado: (2006)

Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs
por: Ketkar, Amit, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hu3o1ch5n4mf4ceijoql11b3vj