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Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer

Stromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis content, vascular invasion, molecular subtypes, tumour detection mode, and...

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Autores principales: Klingen, Tor A., Chen, Ying, Aas, Hans, Wik, Elisabeth, Akslen, Lars A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034712/
https://www.ncbi.nlm.nih.gov/pubmed/33836007
http://dx.doi.org/10.1371/journal.pone.0249767
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author Klingen, Tor A.
Chen, Ying
Aas, Hans
Wik, Elisabeth
Akslen, Lars A.
author_facet Klingen, Tor A.
Chen, Ying
Aas, Hans
Wik, Elisabeth
Akslen, Lars A.
author_sort Klingen, Tor A.
collection PubMed
description Stromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis content, vascular invasion, molecular subtypes, tumour detection mode, and patient prognosis in breast cancer. We performed a population based retrospective study of invasive breast cancers from the Norwegian Breast Screening Program (Vestfold County, 2004–2009) including 200 screen-detected and 82 interval cancers. Perivascular fibulin-2 staining was semi-quantitatively graded based on immunohistochemistry (1–3) and dichotomized as high expression (grade 2–3) and low expression (grade 1). Elastosis content was graded on a 4-tiered scale and dichotomized as high (score 3) and low (score 0–2) expression, whereas lymphatic (LVI) and blood vessel invasion (BVI) were recorded as absent or present by immunohistochemistry. High perivascular fibulin-2 expression was strongly related to stromal elastosis (p<0.001), and inversely associated with BVI and LVI (p<0.001 for both). High fibulin-2 was associated with luminal breast cancer subgroups (p<0.001) and inversely with interval cancers compared with screen-detected tumours (p<0.001). By univariate analysis, low perivascular fibulin-2 was associated with reduced recurrence-free survival (p = 0.002) and disease specific survival (p = 0.019). Low perivascular fibulin-2 expression was strongly related to vascular invasion, low stromal elastosis, non-luminal breast cancer subtypes, interval presentation, and adverse prognosis.
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spelling pubmed-80347122021-04-15 Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer Klingen, Tor A. Chen, Ying Aas, Hans Wik, Elisabeth Akslen, Lars A. PLoS One Research Article Stromal elastosis is related to good prognosis in breast cancer and fibulin-2 helps to stabilize elastic fibers in basement membranes. Here, we examined the level of perivascular fibulin-2 expression in relation to elastosis content, vascular invasion, molecular subtypes, tumour detection mode, and patient prognosis in breast cancer. We performed a population based retrospective study of invasive breast cancers from the Norwegian Breast Screening Program (Vestfold County, 2004–2009) including 200 screen-detected and 82 interval cancers. Perivascular fibulin-2 staining was semi-quantitatively graded based on immunohistochemistry (1–3) and dichotomized as high expression (grade 2–3) and low expression (grade 1). Elastosis content was graded on a 4-tiered scale and dichotomized as high (score 3) and low (score 0–2) expression, whereas lymphatic (LVI) and blood vessel invasion (BVI) were recorded as absent or present by immunohistochemistry. High perivascular fibulin-2 expression was strongly related to stromal elastosis (p<0.001), and inversely associated with BVI and LVI (p<0.001 for both). High fibulin-2 was associated with luminal breast cancer subgroups (p<0.001) and inversely with interval cancers compared with screen-detected tumours (p<0.001). By univariate analysis, low perivascular fibulin-2 was associated with reduced recurrence-free survival (p = 0.002) and disease specific survival (p = 0.019). Low perivascular fibulin-2 expression was strongly related to vascular invasion, low stromal elastosis, non-luminal breast cancer subtypes, interval presentation, and adverse prognosis. Public Library of Science 2021-04-09 /pmc/articles/PMC8034712/ /pubmed/33836007 http://dx.doi.org/10.1371/journal.pone.0249767 Text en © 2021 Klingen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Klingen, Tor A.
Chen, Ying
Aas, Hans
Wik, Elisabeth
Akslen, Lars A.
Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
title Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
title_full Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
title_fullStr Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
title_full_unstemmed Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
title_short Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
title_sort fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034712/
https://www.ncbi.nlm.nih.gov/pubmed/33836007
http://dx.doi.org/10.1371/journal.pone.0249767
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